Active Recombinant Mouse Il22 Protein (147 aa)
|Product Overview :||Recombinant MouseIL-22 produced in E. coli is a single non-glycosylated polypeptide chain containing 147 amino acids. A fully biologically active molecule, rmIL-22 has a molecular mass of 16.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.|
- Gene Information
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|Description :||Interleukin-22 (IL-22) is a member of a group of cytokines called the IL-10 family which include IL-10,IL-19, IL-20, IL-24, and IL-26. IL-22 shares use of the IL-10R2 in cell signaling with other members of this family IL-22 signals through a receptor system consisting of IL-10R-ß/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. IL-22 is produced by activated DCs and T cells and initiates an innate immune response against bacterial pathogens especially in epithelial cells such as those in the respiratory tract and gut. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and can also be produced by Th17 cells, which plays a likely role in the coordinated response of both adaptive and innate immune systems.|
|Source :||E. coli|
|Form :||Sterile Filtered White lyophilized (freeze-dried) powder.|
|Bio-activity :||ED50 < 0.5 ng/mL. Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells).|
|Molecular Mass :||16.8 kDa, observed by reducing SDS-PAGE|
|Protein Length :||147|
|AA Sequence :||MLPVNTRCKLEVSNFQQPYIVNRTF MLAKEASLADNNTDVRLIGEKLFRG VSAKDQCYLMKQVLNFTLEDVLLPQ SDRFQPYMQEVVPFLTKLSNQLSSC HISGDDQNIQKNVRRLKETVKKLGE SGEIKAIGELDLLFMSLRNACV|
|Endotoxin :||< 0.2 EU/μg, determined by LAL method.|
|Purity :||> 98% as analyzed by SDS-PAGE& HPLC.|
|Storage :||Lyophilized recombinant Mouse IL-22 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Mouse IL-22 should be stable up to 1 week at 4 centigrade or up to 3 months at -20 centigrade.|
|Storage Buffer :||Lyophilized after extensive dialysis against PBS.|
|Reconstitution :||Reconstituted in ddH2O or PBS at 100 μg/mL.|
|Gene Name :||Il22 interleukin 22 [ Mus musculus ]|
|Official Symbol :||Il22|
|Synonyms :||IL22; interleukin 22; interleukin-22; ILTIF alpha; IL-TIF alpha; interleukin-22a; IL-10-related T-cell-derived-inducible factor; interleukin 10-related T cell-derived inducible factor; IL-22; Iltif; IL-22a; ILTIFa; MGC129416; MGC129417;|
|Gene ID :||50929|
|mRNA Refseq :||NM_016971|
|Protein Refseq :||NP_058667|
|UniProt ID :||Q14BB3|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
IL22 enhances gut epithelial repair mechanisms.
IL22 activates STAT3 to modulate downstream targets.
IL22 interacts synergistically with IL-17 during inflammation.
IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.
IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.
IL22 expression is upregulated in psoriasis.
IL22 expression is upregulated during viral infections like Hepatitis C.
IL22 contributes to anti-tumor immunity by activating NK cells.
IL22 promotes Th22 cell differentiation.
IL22 polymorphisms affect its binding affinity and signaling.
Customer Reviews (3)Write a review
High specificity. -
Good for Th17 differentiation. -
Effective in gut repair assays. -
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