Active Recombinant Mouse Il22 Protein, His-Tagged
|Product Overview :||Recombinant mouse Il22 Protein, His-tagged was expressed in E. coli cell|
- Gene Information
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|Description :||Interleukin-22 (IL-22) a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL-22 is produced by activated NK and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive innate immune systems, autoimmunity and tissue regeneration.|
|Source :||Escherichia coli|
|Form :||Lyophilized powder|
|AA Sequence :||MLPVNTRCKLEVSNFQQPYIVNRTF MLAKEASLADNNTDVRLIGEKLFRG VSAKDQCYLMKQVLNFTLEDVLLPQ SDRFQPYMQEVVPFLTK
LSNQLSSCHISGDDQNIQKNVRRLK ETVKKLGESGEIKAIGELDLLFMSL RNACV with polyhistidine tag at the C-terminus
|Endotoxin :||<0.1 EU per 1 μg of the protein by the LAL method.|
|Bio-activity :||Measure by its ability to induce IL-10 secretion in COLO205 cells. The ED50 for this effect is <0.3 ng/mL.|
|Purity :||>98% as determined by SDS-PAGE. Ni-NTA chromatography|
|Storage Buffer :||The protein was lyophilized from a solution containing 1X PBS, pH 7.4.|
|Reconstitution :||It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.|
|Storage :||Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.|
|Notes :||Please use within one month after protein reconstitution.|
|Gene Name :||Il22 interleukin 22 [ Mus musculus (house mouse) ]|
|Official Symbol :||Il22|
|Synonyms :||L-22; If2b1; Iltif; IL-22a; ILTIFa|
|Gene ID :||50929|
|mRNA Refseq :||NM_016971.2|
|Protein Refseq :||NP_058667.1|
|UniProt ID :||Q14BB3|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
IL22 enhances gut epithelial repair mechanisms.
IL22 activates STAT3 to modulate downstream targets.
IL22 interacts synergistically with IL-17 during inflammation.
IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.
IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.
IL22 expression is upregulated in psoriasis.
IL22 expression is upregulated during viral infections like Hepatitis C.
IL22 contributes to anti-tumor immunity by activating NK cells.
IL22 promotes Th22 cell differentiation.
IL22 polymorphisms affect its binding affinity and signaling.
Customer Reviews (3)Write a review
High specificity. -
Good for Th17 differentiation. -
Effective in gut repair assays. -
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