Recombinant Human TIMP Metallopeptidase Inhibitor 2 TIMP2-5141H

Recombinant Human TIMP Metallopeptidase Inhibitor 2

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Recombinant Human TIMP Metallopeptidase Inhibitor 2

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Cat. No. : TIMP2-5141H
Product Overview : Recombinant human TIMP2was expressed in E. coli and purified by using SDS PAGE and HPLC.
Description : TIMP2 is anextracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13,14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversibleprotease inhibitors that function as key modulators of extracellular matrixdegradation during tissue development and remodeling. TIMP2 can also actthrough an MMP-independent mechanism inhibiting endothelial cellproliferation in vitro and demonstrates anti-angiogenic activities in vivo.
Source : Human
Host : E.coli
Form : Suppliedas a lyophilized powder.
Purity : >95% pure by SDSPAGE and HPLC
Sequence : Region of TIMP2protein corresponding to amino acids MCSCSPVHPQ QAFCNADVVI RAKAVSEKEVDSGNDIYGNP IKRIQYEIKQ IKMFKGPEKD IEFIYTAPSS AVCGVSLDVG GKKEYLIAGK AEGDGKMHITLCDFIVPWDT LSTTQKKSLN HRYQMGCECK ITRCPMIPCY ISSPDECLWM DWVTEKNING HQAKFFACIKRSDGSCAWYR GAAP
Molecular Mass : 21.8 kDa
Applications : Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
Storage : Storeat 4 deg C until reconstitution. Following reconstitution aliquot and freezeat -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol : TIMP2
PDBrendering based on 1bqq. :

Gene Name : TIMP2TIMP metallopeptidase inhibitor 2 [ Homo sapiens ]
Synonyms : TIMP2; TIMP metallopeptidase inhibitor 2; CSC-21K;metalloproteinase inhibitor 2; TIMP-2; OTTHUMP00000205879; tissue inhibitorof metalloproteinase 2; tissue inhibitor of metalloproteinases 2
Gene ID : 7077
mRNA Refseq : NM_003255
Protein Refseq : NP_003246
MIM : 188825
UniProt ID : P16035
Chromosome Location : 17q25
Pathway : MatrixMetalloproteinases
Function : enzymeactivator activity; enzyme inhibitor activity; integrin binding; metal ionbinding; metalloendopeptidase inhibitor activity

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