Recombinant Human TIMP Metallopeptidase Inhibitor 2

• Cat.No.: TIMP2-5141H
• Product Overview: Recombinant human TIMP2was expressed in E. coli and purified by using SDS PAGE and HPLC.

Specification

• Cat. No.: TIMP2-5141H
• Description: TIMP2 is anextracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13,14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversibleprotease inhibitors that function as key modulators of extracellular matrixdegradation during tissue development and remodeling. TIMP2 can also actthrough an MMP-independent mechanism inhibiting endothelial cellproliferation in vitro and demonstrates anti-angiogenic activities in vivo.
• Source: Human
• Host: E.coli
• Form: Suppliedas a lyophilized powder.
• Purity: >95% pure by SDSPAGE and HPLC
• Sequence: Region of TIMP2protein corresponding to amino acids MCSCSPVHPQ QAFCNADVVI RAKAVSEKEVDSGNDIYGNP IKRIQYEIKQ IKMFKGPEKD IEFIYTAPSS AVCGVSLDVG GKKEYLIAGK AEGDGKMHITLCDFIVPWDT LSTTQKKSLN HRYQMGCECK ITRCPMIPCY ISSPDECLWM DWVTEKNING HQAKFFACIKRSDGSCAWYR GAAP
• Molecular Mass: 21.8 kDa
• Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
• Storage: Storeat 4 deg C until reconstitution. Following reconstitution aliquot and freezeat -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: TIMP2

Gene Information

• Gene Name: TIMP2TIMP metallopeptidase inhibitor 2 [ Homo sapiens ]
• Synonyms: TIMP2; TIMP metallopeptidase inhibitor 2; CSC-21K;metalloproteinase inhibitor 2; TIMP-2; OTTHUMP00000205879; tissue inhibitorof metalloproteinase 2; tissue inhibitor of metalloproteinases 2
• Gene ID: 7077
• mRNA Refseq: NM_003255
• Protein Refseq: NP_003246
• MIM: 188825
• UniProt ID: P16035
• Chromosome Location: 17q25
• Pathway: MatrixMetalloproteinases
• Function: enzymeactivator activity; enzyme inhibitor activity; integrin binding; metal ionbinding; metalloendopeptidase inhibitor activity