Recombinant Human Midkine (neurite growth-promoting factor 2) MDK-5077H

Recombinant Human Midkine (neurite growth-promoting factor 2)

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Recombinant Human Midkine (neurite growth-promoting factor 2)

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Cat. No. : MDK-5077H
Product Overview : Recombinant human MDKwas expressed in E. coli and purified recombinant Human MDK protein.
Description : MDK and itsfunctionally-related protein Pleiotrophin are heparin-binding neurotrophicfactors that signal through the same receptor, known as anaplastic lymphomakinase (ALK). MDK plays an important regulatory role inepithelial-mesenchymal interactions during fetal development and in postnatallung development. MDK chemoattracts embryonic neurons, neutrophils andmacrophages, and by signaling through the ALK receptor it exerts angiogenic,growth and survival activities during tumorgenesis.
Source : Human
Host : E. coli
Form : Lyophilized fromPBS, pH 7.4. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Purity : > 98% pure by SDSPAGE and HPLC
Sequence : Region of Midkineprotein corresponding to amino acids VAKKKDKVKK GGPGSECAEW AWGPCTPSSKDCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETIRVTKPCTPKT KAKAKAKKGK GKD.
Molecular Mass : 13.4 kDa
Applications : Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
Storage : Store at 4 deg Cuntil reconstitution. Following reconstitution aliquot and freeze at -20 degC for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol : MDK
PDB rendering basedon 1mkc. :

Gene Name : MDK midkine (neuritegrowth-promoting factor 2) [ Homo sapiens ]
Synonyms : MDK; midkine (neuritegrowth-promoting factor 2); MK; NEGF2; FLJ27379; midkine; ARAP;amphiregulin-associated protein; midgestation and kidney protein; neuriteoutgrowth-promoting protein; neurite outgrowth-promoting factor; MK1; Neuriteoutgrowth-promoting factor 2; OTTHUMP000001970422; OTTHUMP000001970412;OTTHUMP000001970452
Gene ID : 4192
mRNA Refseq : NM_001012333
Protein Refseq : NP_001012333
MIM : 162096
UniProt ID : P2174
Chromosome Location : 11p11.2
Pathway : Glypican 2 network;Syndecan-4-mediated signaling events
Function : growth factor activity; heparinbinding

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