Recombinant Human Midkine (neurite growth-promoting factor 2)

• Cat.No.: MDK-5077H
• Product Overview: Recombinant human MDKwas expressed in E. coli and purified recombinant Human MDK protein.

Specification

• Cat. No.: MDK-5077H
• Description: MDK and itsfunctionally-related protein Pleiotrophin are heparin-binding neurotrophicfactors that signal through the same receptor, known as anaplastic lymphomakinase (ALK). MDK plays an important regulatory role inepithelial-mesenchymal interactions during fetal development and in postnatallung development. MDK chemoattracts embryonic neurons, neutrophils andmacrophages, and by signaling through the ALK receptor it exerts angiogenic,growth and survival activities during tumorgenesis.
• Source: Human
• Host: E. coli
• Form: Lyophilized fromPBS, pH 7.4. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
• Purity: > 98% pure by SDSPAGE and HPLC
• Sequence: Region of Midkineprotein corresponding to amino acids VAKKKDKVKK GGPGSECAEW AWGPCTPSSKDCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETIRVTKPCTPKT KAKAKAKKGK GKD.
• Molecular Mass: 13.4 kDa
• Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
• Storage: Store at 4 deg Cuntil reconstitution. Following reconstitution aliquot and freeze at -20 degC for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: MDK

Gene Information

• Gene Name: MDK midkine (neuritegrowth-promoting factor 2) [ Homo sapiens ]
• Synonyms: MDK; midkine (neuritegrowth-promoting factor 2); MK; NEGF2; FLJ27379; midkine; ARAP;amphiregulin-associated protein; midgestation and kidney protein; neuriteoutgrowth-promoting protein; neurite outgrowth-promoting factor; MK1; Neuriteoutgrowth-promoting factor 2; OTTHUMP000001970422; OTTHUMP000001970412;OTTHUMP000001970452
• Gene ID: 4192
• mRNA Refseq: NM_001012333
• Protein Refseq: NP_001012333
• MIM: 162096
• UniProt ID: P2174
• Chromosome Location: 11p11.2
• Pathway: Glypican 2 network;Syndecan-4-mediated signaling events
• Function: growth factor activity; heparinbinding