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Official Full Name midkine
Background This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Synonyms MDK; midkine; MK; Mek; retinoic acid-responsive protein; retinoic acid-induced differentiation factor;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • S
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MDK-11H Recombinant Human Midkine Protein, His/S-tagged E.coli His/S
    Human MDK-197H Recombinant Human MDK protein E.coli N/A
    Human MDK-30202TH Recombinant Human MDK E.coli N/A
    Human MDK-384H Recombinant Human Midkine, His-tagged E.coli His
    Human MDK-440H Recombinant Human MDK protein, GST-tagged E. coli GST
    Human MDK-441H Recombinant Human MDK protein, His-tagged E. coli His
    Human MDK-442H Recombinant Human MDK protein, GST-tagged E. coli GST
    Human MDK-4496H Recombinant Human MDK Protein, GST-tagged Wheat Germ GST
    Human MDK-506H Recombinant Human MDK, His-tagged E.coli His
    Human MDK-5077H Recombinant Human Midkine (neurite growth-promoting factor 2) Human N/A
    Human MDK-538H Recombinant Human MDK protein E.coli N/A
    Human MDK-553H Recombinant Human MDK, None tagged Insect Cell N/A
    Human MDK-568HCL Recombinant Human MDK cell lysate Insect Cell N/A
    Human MDK-5862H Recombinant Human MDK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MDK-5931H Recombinant Human MDK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MDK-668H Recombinant Human MDK Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MDK-6917H Recombinant Human Midkine (neurite growth-promoting factor 2), His-tagged E.coli His
    Mouse Mdk-124M Recombinant Mouse Mdk Protein E.coli
    Mouse Mdk-12M Recombinant Mouse Midkine Protein, His/S-tagged E.coli His/S
    Mouse Mdk-4005M Recombinant Mouse Mdk Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Mdk-567M Recombinant Mouse Mdk protein E.coli N/A
    Rat Mdk-637R Recombinant Rat Mdk protein, His-tagged E.coli His
    Rat Mdk-92R Recombinant Rat Mdk protein E.coli N/A
    Chicken MDK-3799C Recombinant Chicken MDK Mammalian Cell His

    mdk involved in several pathways and played different roles in them. We selected most pathways mdk participated on our site, such as Glypican 2 network, NOTCH2 Activation and Transmission of Signal to the Nucleus, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with mdk were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glypican 2 network MDK
    NOTCH2 Activation and Transmission of Signal to the Nucleus MDKB; MDKA; CNTN1; MIB1; MDK
    Signal Transduction PTPRU; ADAM12; ARHGAP10; RBP2A; ARHGEF3; KREMEN2; AXL; ABCA4A; OR52B4; RLN3
    Signaling by NOTCH2 MDKB; MDK; MDKA
    Syndecan-4-mediated signaling events MDK; ADAM12; GIPC1

    mdk has several biochemical functions, for example, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by mdk itself. We selected most functions mdk had, and list some proteins which have the same functions with mdk. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity MDKA; FGF5; Kitl; COL20A1; PRL2C2; ANGPTL3; GPI; FGF12B; GFER; HDGF
    heparin binding F11; VEGFA; SLIT2; PTPRF; MDK; NAV2; FGF4; COL5A1; BMP7; CTGFB

    mdk has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mdk here. Most of them are supplied by our site. Hope this information will be useful for your research of mdk.


    Hugosson, F; Sjogren, C; et al. The Drosophila Midkine/Pleiotrophin Homologues Miple1 and Miple2 Affect Adult Lifespan but Are Dispensable for Alk Signaling during Embryonic Gut Formation. PLOS ONE 9:-(2014).
    Kojima, H; Kosugi, T; et al. Deficiency of Growth Factor Midkine Exacerbates Necrotizing Glomerular Injuries in Progressive Glomerulonephritis. AMERICAN JOURNAL OF PATHOLOGY 182:410-419(2013).

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