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Recombinant Human Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, GST-tagged

Cat.No. : PDGFRA-1287H
Product Overview : Recombinant humanPDGFRA catalytic domain (amino acids 550-1089), GST-tagged was expressed ininsect cells. Its molecular weight is 89800 Dalton.
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  • Gene Information
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Cat. No. : PDGFRA-1287H
Description : PDGFRA is a cellsurface receptor tyrosine kinase which binds members of the platelet-derivedgrowth factor family. No special measures were taken to activate this kinase.PDGFRA encodes a cell surface tyrosine kinase receptor for members of theplatelet-derived growth factor family. These growth factors are mitogens forcells of mesenchymal origin. The identity of the growth factor bound to areceptor monomer determines whether the functional receptor is a homodimer ora heterodimer, composed of both platelet-derived growth factor receptor alphaand beta polypeptides.
Source : Insect cells
Species : Human
Form : Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT + 50%glycerol.
Molecular Weight : 89.8 kDa
Storage : Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : PDGFRA
Gene Name : PDGFRA platelet-derived growth factor receptor,alpha polypeptide [ Homo sapiens ]
Synonyms : PDGFRA;platelet-derived growth factor receptor, alpha polypeptide; CD140A; CD140a;PDGFR2; MGC74795; RHEPDGFRA; Alpha-type platelet-derived growth factorreceptor; EC 2.7.10.1; PDGF-R-alpha; CD140 antigen-like family member A;CD140a antigen
Gene ID : 5156
mRNA Refseq : NM_006206
Protein Refseq : NP_006197
MIM : 173490
UniProt ID : P16234
Chromosome Location : 4q12
Pathway : ATF-2 transcriptionfactor network; Calcium signaling pathway; Cytokine-cytokine receptorinteraction; Downstream signal transduction; Endocytosis; Focal adhesion; Gapjunction; Glioma; HTLV-I infection; MAPK signaling pathway; Melanoma;Pathways in cancer; PDGFR-alpha signaling pathway; Regulation of actin cytoskeleton;Signaling by PDGF
Function : ATP binding; growthfactor binding; nucleotide binding; phosphatidylinositol 3-kinase binding;platelet-derived growth factor alpha-receptor activity; platelet-derivedgrowth factor binding; platelet-derived growth factor receptor binding;protein homodimerization activity; protein tyrosine kinase activity; receptoractivity; transmembrane receptor protein tyrosine kinase activity; vascularendothelial growth factor-activated receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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