PDGFRA
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Official Full Name
platelet-derived growth factor receptor, alpha polypeptide
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Overview
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide; platelet-derived growth factor receptor alpha; CD140a; PDGFR2; PDGFR-alpha; PDGF-R-alpha; CD140a antigen; PDGFRA/BCR fusion; CD140 antigen-like family member A; platelet-derived growth factor receptor 2; alpha-type platelet-derived growth factor receptor; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; CD140A; PDGFR-2; RHEPDGFRA; MGC74795;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chromatography Reagents
- Assay Kits
- Chicken
- Gln24-Glu524
- Human
- Human
- Mouse
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- E.coli
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- HEK293 cells
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- Human
- Human Cell
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- DDDDK
- Fc
- Flag
- GST
- His
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PDGFRA involved in several pathways and played different roles in them. We selected most pathways PDGFRA participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | AKT2;HRASB;MAP2K7;PAK2;RAC1B;NGF;HSPA1B;PPM1B;CDC42L2 |
| Ras signaling pathway | PRKCA;PRKCG;RRAS2;NGFR;PIK3CB;GNB3;SHC2;RAF1;SHC3 |
| Rap signaling pathway | Pdgfa&Pdgfb;PIK3R3;LPAR2;FGF10;PDGFA;ITGB3;FGFR4;GNAI3;RAC3 |
| Calcium signaling pathway | HTR6;PRKCBA;CHRM3;PLCG2;ATP2B1A;NOS1;PLCD4;ATP2B4;GRM1 |
| Cytokine-cytokine receptor interaction | PRL2;TNFRSF17;IL28A;LIFR;TNFRSF9A;IL7R;IL11RA2;TNFRSF25;INHBB |
| Phospholipase D signaling pathway | AGTR1A;PTK2B;AVPR1B;ARF6;LPAR4;GRM7;PDGFC;CYTH4;GRM1 |
| Endocytosis | SMAD2;MHC1UEA;EGFRA;SMURF2;SH3GL2;ARFGEF2;DNM1A;ACAP2;RAB5AB |
| PIK-Akt signaling pathway | KRAS;IL2RA;IFNA13;GNB4;CCND2;GNG11;IFNA17;LAMA3;NOS3 |
| Focal adhesion | VEGFB;PTK2AA;COL27A1A;PAK2;CCND2;RAPGEF1;GSK3AA;MYL10;COL5A2 |
| Gap junction | PDGFA;HRAS;CSNK1DA;TUBA1L;TUBA8L;GNAQ;TUBA8L2;GRB2B;TUBAL3 |
| Regulation of actin cytoskeleton | Itgam&Itgb2;MYL7;APC2;SCINLA;MYL9A;ARPC5LB;BCAR1;PFN4;MYL12.2 |
| HTLV-I infection | FZD1;KRAS;TGFB3;MYBL2;POLE3;HLA-DMB;ITGB2L;Pdgfa&Pdgfb;H2-AB1 |
| Pathways in cancer | HSP90AA1;BMP4;RAC3;APC2;FADD;HGF;BIRC2;GNG8;GNG3 |
| MicroRNAs in cancer | PRKCA;IRS2;DNMT3B;BMI1;SHC4;SOX4;THBS1;MTOR;TTC6 |
| Glioma | CALML3;PIK3CA;MAPK3;PIK3R3;ARAF;CAMK2B;CALM3;PIK3CB;PIK3R5 |
| Prostate cancer | PDGFD;NFKBIA;TRP53;Pdgfa&Pdgfb;INS1;CCNE2;GRB2;LEF1;MAPK1 |
| Melanoma | CCND1;PIK3R5;HGF;TP53;MAP2K2;FGF4;PDGFB;FGF1;FGF10 |
| Central carbon metabolism in cancer | MAP2K2;NTRK1;PFKP;IDH1;C12orf5;KRAS;PIK3R1;MTOR;G6PDX |
| Choline metabolism in cancer | GRB2;DGKE;PLCG1;SLC44A2;RHEB;SLC22A2;CHKA;WASF1;PDGFD |
PDGFRA has several biochemical functions, for example, ATP binding, platelet-derived growth factor alpha-receptor activity, platelet-derived growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFRA itself. We selected most functions PDGFRA had, and list some proteins which have the same functions with PDGFRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP2C1;STK40;MAP3K6;HELZ;GLULA;NME2B.1;MST1R;NLRP9B;DYRK2 |
| platelet-derived growth factor alpha-receptor activity | |
| platelet-derived growth factor binding | Pdgfa&Pdgfb;COL2A1;PDGFA;COL6A1;COL5A1;COL4A1;COL1A1;COL1A2;PDGFB |
| platelet-derived growth factor receptor binding | PDGFAA;Pdgfa&Pdgfb;VEGFA;TYMP;PDGFAB;PDGFRB;PTEN;LYN;PDGFRA |
| protein binding | CDON;ERLIN2;C11orf65;SERPINE1;HTR1A;SEC24D;MRPL51;SUN1;ZNF266 |
| protein homodimerization activity | ADRB2;MECOM;TGFB1;RAB11FIP2;FLT3;DMBX1;PLEK;ACOT7;NOS1 |
| protein kinase activity | JAK2;RPS6KA3B;PRKCBA;TBK1;KALRN;PRKD2;ARAF;SOX9;PDGFRA |
| transmembrane receptor protein tyrosine kinase activity | TIE1;IGF1RA;TYRO3;FGFR1B;RYK;PDGFRA;ALK;EPHA2A;NPTNB |
| vascular endothelial growth factor binding | KDR;PDGFRA;PDGFRB;NRP1 |
| vascular endothelial growth factor-activated receptor activity | PDGFRA;FLT1;NRP1B;KDR;NRP1A;FLT4;NRP1;FLT3;NRP2 |
PDGFRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFRA here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFRA.
PDGFB; CRK; PDGFA
Gene Family
Research Area
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Customer Reviews (3)
Write a reviewThe staff had a good attitude, actively communicated with me and solved many technical problems.
Cheap price, high quality products, worth buying again!
The high quality of the purchased protein helped me to obtain satisfactory experimental results.
Q&As (4)
Ask a questionOverexpression of PAGFRA promotes cancer cell proliferation and invasion and inhibits apoptosis.
PDGFRA is involved in physiological processes such as normal organ development, tissue damage repair and malignant tumor progression.
PDGFRA is closely related to the study of gastrointestinal mesenchymal tumors, ovarian cancer and other diseases.
PDGFRA binds to PDGF to regulate cell proliferation and differentiation.
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