PDGFRA
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Official Full Name
platelet-derived growth factor receptor, alpha polypeptide -
Overview
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
PDGFRA;platelet-derived growth factor receptor, alpha polypeptide;platelet-derived growth factor receptor alpha;CD140a;PDGFR2;PDGFR-alpha;PDGF-R-alpha;CD140a antigen;PDGFRA/BCR fusion;CD140 antigen-like family member A;platelet-derived growth factor receptor 2;alpha-type platelet-derived growth factor receptor;rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein;CD140A;PDGFR-2;RHEPDGFRA;MGC74795
Recombinant Proteins
- Human
- Chicken
- Rat
- Cynomolgus
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cells
- Insect Cells
- Human Cells
- C-His
- Human
- Sf9 Cells
- GST
- His
- Non
- Fc
- Flag
- Avi
- DDK
- Myc
Involved Pathway
PDGFRA involved in several pathways and played different roles in them. We selected most pathways PDGFRA participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IL13RA1,IL28RA,IFNK,IFNB,CXCL6,CCL4L2,LEP,GM-CSF,IL23R,ACKR3B |
| Ras signaling pathway | AKT1,PDGFRB,GNB2,TBK1,VEGFA,FGF1,BAD,GNGT1,PLA2G4A,FGF6 |
| Gap junction | TUBB5,PDGFC,TUBA8L,MAPK3,MAPK7,GNAS,RAF1,PRKCB,GNAI2,GUCY1A3 |
| HTLV-I infection | CCND1,TBPL2,MSX1,HLA-DMB,WNT1,CDC16,MRAS,RRAS2,WNT8A,CDC23 |
| MAPK signaling pathway | PDGFAA,ELK4,NLK1,NFATC3,NFKB2,PAK2A,NGF,FGF5,MAP3K5,RPS6KA3A |
| Central carbon metabolism in cancer | PDHA1,PFKP,PKM2,HK2,PKM,IDH1,SIRT3,PIK3CG,TP53,G6PDX |
| MicroRNAs in cancer | HMOX1,APC,PRKCG,RHOA,IRS2,DNMT1,PLAU,CCND1,BMI1,TPM1 |
| Focal adhesion | PDGFB,RHOAD,ITGB7,RAC2,CCND1,PPP1R12C,PIK3CD,THBS1,MYL9,GSK3B |
| Melanoma | MITF,PDGFRB,HRAS,PDGFC,FGF19,AKT2,FGF21,PTEN,FGF4,FGF2 |
Protein Function
PDGFRA has several biochemical functions, for example, ATP binding,platelet-derived growth factor alpha-receptor activity,platelet-derived growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFRA itself. We selected most functions PDGFRA had, and list some proteins which have the same functions with PDGFRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane receptor protein tyrosine kinase activity | FGFR1A,LTK,KITB,EPHA4A,KDRL,ERBB4A,DDR2,EPHA4B,RET,KITA |
| protein kinase activity | CDK8,RPS6KA3,SYK,DYRK1A,PTK7A,ARAF,JAK2A,STK17B,NTRK2B,ABL1 |
| platelet-derived growth factor binding | COL4A1,PDGFB,PDGFRB,COL2A1,PDGFA,COL5A1,COL1A1,COL3A1,COL1A2,COL6A1 |
| vascular endothelial growth factor binding | PDGFRB,NRP1,KDR |
| vascular endothelial growth factor-activated receptor activity | NRP2B,NRP2A,FLT3,NRP1B,NRP1,NRP2,KDR,FLT4,FLT1,NRP1A |
| protein binding | NAV2,TMF1,CITED2,C16orf79,MAGEH1,CYTH1,TNFSF14,ACLY,CRTAC1,TSC22D1 |
| ATP binding | GART,EARS2,CLK3,EPHB3,ASNS,UCK2A,TP53RK,KIF5A,KIF2B,ATP2B1A |
| platelet-derived growth factor receptor binding | PDGFC,TYMP,VEGFA,PDGFA,ITGB3,ITGA5,FIGF,PDGFB,PDGFAA,PDGFAB |
| protein homodimerization activity | DAPK3,ASMT,IL6R,OXA1L,AMICA1,SYT6,HINT2,RPS19,CORO1A,BMPR1A |
Interacting Protein
PDGFRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFRA here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFRA.
PDGFB;CRK;PDGFA
Resources
Gene Families
Research Area
- Cancer Drug Targets
- Cytokine and Growth Factor Receptors on VSMC
- Other CD Antigen
- Receptor Tyrosine Kinases (RTKs)
- Inflammatory Mediators
- Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
- Negative Regulators of the Jak/STAT Pathway
- Receptors in the Jak/STAT Pathway
- Mesenchymal Stem Cell Markers
- Neural Stem Cell Markers
- Glial Lineage Markers
- PDGF Receptor
- Mesodermal Lineage Markers
- Glioma Biomarkers
- Oncoprotein-Growth Factor Receptors
Related Services
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References
- Yi, JH; Park, BB; et al. Retrospective analysis of extra-gastrointestinal stromal tumors. WORLD JOURNAL OF GASTROENTEROLOGY 21:1845-1850(2015).
- Albuquerque, A; Rios, E; et al. Evaluation of clinico-pathological features and Helicobacter pylori infection in gastric inflammatory fibroid polyps. VIRCHOWS ARCHIV 465:643-647(2014).
