Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Mouse Adam17 protein, His-tagged

Cat.No. : Adam17-522M
Product Overview : Recombinant Mouse Adam17 protein(Pro 18 - Asp 563), fused with His tag, was expressed in HEK293.
  • Specification
  • Gene Information
  • Related Products
Source : HEK293
Species : Mouse
Tag : His
Form : Lyophilized from 0.22 μm filtered solution in 50 mM MES, 150 mM NaCl, pH6.5. Normally trehalose is added as protectant before lyophilization.
Molecular Mass : This protein carries a polyhistidine tag at the C-terminus.The protein has a calculated MW of 63.4 kDa. The protein migrates as 19 kDa and 20 kDa (Propeptide), 55-66 kDa (Mature-ADAM17) and 75-94 kDa (Pro-ADAM17)
under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein Length : Pro 18 - Asp 563
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : Adam17 a disintegrin and metallopeptidase domain 17 [ Mus musculus ]
Official Symbol : Adam17
Synonyms : ADAM17; a disintegrin and metallopeptidase domain 17; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloprotease domain 17; Tace; CD156b;
Gene ID : 11491
mRNA Refseq : NM_009615
Protein Refseq : NP_033745

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (10)

Ask a question
Is ADAM17 protein involved in the renin-angiotensin system? 08/01/2022

ADAM17 is a negative regulator of the RAS system.

My research requires high protein purity, can I customize > 90% ADAM17 protein? 06/05/2022

Yes, we have produced ADAM17 protein of this purity.

What proteins does ADAM17 cleave? 04/07/2022

ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.

Where ADAM17 is highly expressed? 06/25/2021

ADAM17 is widely expressed in somatic and immune cells

In addition to Diabetes mellitus and cardiomyopathy-related research, ADAM17 is currently used in the research of which diseases? 01/21/2021

ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.

Is ADAM17 associated with the EGFR-PI3K-AKT pathway? 10/03/2020

ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.

Does the package insert for ADAM17 contain detailed information on the handling of the lyophilized powder product? 04/19/2020

The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.

ADAM17 protein is also involved in recent activities? 12/11/2019

Yes, ADAM17 protein is involved in this promotion.

Does ADAM17 mediate the Notch pathway? 10/05/2019

ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.

Does adding His tag have any effect on protein? 04/24/2019

Addition of His tags usually does not affect the function, properties of the target protein.

Customer Reviews (3)

Write a review
Reviews
04/08/2022

    Cheap price, high quality products, worth buying again

    03/15/2019

      The high quality of the purchased protein helped me to obtain satisfactory experimental results.

      02/26/2019

        Good after-sales service attitude, helped me solve a lot of problems in the experiment.

        Ask a Question for All Adam17 Products

        Required fields are marked with *

        My Review for All Adam17 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends