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Recombinant Mouse A Disintegrin And Metallopeptidase Domain 17, His-tagged

Cat. No.: Adam17-522M
Product Overview: Recombinant mouse Adam17protein was expressed in Murine myeloma cell line. Pro18-Arg214 and Asp59-Arg214both with a C-terminal 10-His tag. Pro18-Asp563 and Arg215-Asp563.
Description: Adam17 is a memberof the ADAM family that contains a disintegrin and metalloproteaselike domain.The domain structure of mouse Adam17 consists of pro (aa 18 - 214), catalytic(aa 215 - 474), disintegrinlike (aa 475 - 563), cysteinerich (aa 564 - 602), Crambinlike(aa 603 - 671), transmembrane (aa 672 - 692), and cytoplasmic (aa 693 - 827).Recombinant mouse Adam17 ends after the disintegrinlike domain and consistsof several forms as described.
Source: Murine myeloma cellline, NS0-derived.
Form: Lyophilized from a0.2 μm filtered solution in MES and NaCl.
N-terminalSequence: Pro18, Asp59 &Arg215
Molecular Weight: 63 kDa,40 kDa, 23 kDa, 18 kDa
Activity: Measuredby its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-DpaRSSSR-NH2.The specific activity is > 500 pmoles/min/μg, as measured under thedescribed conditions.
Endotoxin Level: < 1.0 EU per 1 μgof the protein by the LAL method.
SDS-PAGE: 76 kDa,63 kDa, 21 kDa and 18 kDa, reducing conditions.
Purity: > 90%, by SDSPAGEunder reducing conditions and visualized by silver stain.
Reconstitution: 100μg/mL in sterile, deionized water.
Storage: Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt,-20 to -70°C as supplied. 3 months, -20 to -70°C under sterile conditionsafter reconstitution.
Gene Name: Adam17 a disintegrin andmetallopeptidase domain 17 [ Mus musculus ]
Official Symbol: Adam17
Synonyms: Adam17; adisintegrin and metallopeptidase domain 17; Tace; CD156b; disintegrin andmetalloproteinase domain-containing protein 17; ADAM 17; TNF-alphaconvertase; TNF-alpha converting enzyme; EC 3.4.24.86
Gene ID: 11491
mRNA Refseq: NM_009615
Protein Refseq: NP_033745
UniProt ID: Q3UEC0
Chromosome Location: 12 A1.3;12 3.0 cM
Pathway: Alzheimer"s disease;Delta-Notch Signaling Pathway; Disease; Notch Signaling Pathway; Regulatedproteolysis of p75NTR; Signal Transduction; Signaling by EGFR; Signaling byEGFR in Cancer; Signalling by NGF; p75 NTR receptor-mediated signalling
Function: PDZ domain binding;SH3 domain binding; hydrolase activity; integrin binding; interleukin-6receptor binding; metal ion binding; metalloendopeptidase activity;metallopeptidase activity; peptidase activity; protein binding; zinc ionbinding

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