|Official Full Name||ADAM metallopeptidase domain 17|
|Background||This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]|
|Synonyms||ADAM17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; ADAM18; CD156B; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
adam17 involved in several pathways and played different roles in them. We selected most pathways adam17 participated on our site, such as Notch signaling pathway, Alzheimers disease, Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with adam17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Notch signaling pathway||HER15.1; JAG2B; ADAM17; CTBP1; APH1C; KAT2A; NOTCH2; DTX3L; DVL3A; NCOR2|
|Alzheimers disease||ATP5F1; MAPK1; CALM3; NDUFA8; COX7B; COX7B2; PLCB2; NCSTN; IL1B; CASP12|
|Epithelial cell signaling in Helicobacter pylori infection||ATP6V1G2; ATP6V0D1; PLCG2; ATP6V1B1; CXCL1; TCIRG1; ATP6V1D; ATP6V1F; ATP6V1G3; MAPK13|
adam17 has several biochemical functions, for example, Notch binding, PDZ domain binding, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by adam17 itself. We selected most functions adam17 had, and list some proteins which have the same functions with adam17. You can find most of the proteins on our site.
|Notch binding||DNER; JAG1B; DLL1; JAG2B; NCOR2; DTX1; DLL3; CHAC1; AAK1; NOTCH4|
|PDZ domain binding||SLC9A3R1; DLC; NLGN1; SLC22A5; ATP2B3A; LPAR1; CXXC4; ARHGEF16; NSF; FZD7|
|SH3 domain binding||NOXA1; MVB12A; DRD4; FUT8; ARHGAP6; SH3BP5LA; REPS1; PDE4D; ABL1; FAM125A|
|integrin binding||ADAMTS8; SEMA7A; FBLN1; TNN; ADAM9; CTGFA; FBN1; ITGB1; ANGPTL3; SYK|
|interleukin-6 receptor binding||ERAP1; ADAM17; CNTF; IL6; PYCARD|
|metalloendopeptidase activity||YBEY; IDE; ADAM2; ADAM21; MEP1A.2; BMP1; MMP7; ADAM5P; ADAM10; ADAMTSL5|
|metallopeptidase activity||TMEM27; ADAM28; HE1A; GM12824; PAPPAB; ADAM9; AGBL4; ADAMTS5; CLCA1; PSMD14|
|protein binding||CDK18; DZIP1; C1orf51; LIN7A; OSTB; PCMT1; RASA1; CST3; CXCL9; NXF2|
|zinc ion binding||MMP13A; KIAA0913; SEC23A; MORC3; TRAF4B; TRIM35-21; PRKCA; KDM2AA; CLIP1; PPARAA|
adam17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adam17 here. Most of them are supplied by our site. Hope this information will be useful for your research of adam17.
DLG1; MAD2L1; APP; ITGB1; PDIA3; JAG1; TGFA; PTPN3; thiF; Sgol2