ADAM17
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Official Full Name
ADAM metallopeptidase domain 17
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Overview
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008] -
Synonyms
ADAM17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; ADAM18; CD156B; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme;
- Recombinant Proteins
- Antibody
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Assay Kits
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- GST
- His
- Fc
- Avi
- T7
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- ADAM17 Related Signal Pathway
ADAM17 involved in several pathways and played different roles in them. We selected most pathways ADAM17 participated on our site, such as Notch signaling pathway, Alzheimers disease, Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | DLL3;PSEN2;NCOR2;DLA;DVL1B;JAG2B;ADAM17;DLL4;HER15.1 |
| Alzheimers disease | PLCB1;SNCA;CALM2;NDUFS5;ATP2A1;NDUFC2-KCTD14;NDUFA6;CALM4;MAPK1 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V1E2;GIT1;PAK1;ATP6V1D;RAC1;TJP1;CDC42;MAPK13;NFKBIA |
ADAM17 has several biochemical functions, for example, Notch binding, PDZ domain binding, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM17 itself. We selected most functions ADAM17 had, and list some proteins which have the same functions with ADAM17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Notch binding | JAG1;DLL1;JAG1B;NCOR2;NOTCH1;DTX1;CHAC1;DNER;GALNT11 |
| PDZ domain binding | CXXC4;SNTB1;DOCK4;LPAR1;SLC22A5;GIPC1;KIDINS220;ATP2B1A;SRR |
| SH3 domain binding | SH3BP1;ADAM12;MAPT;NCKIPSD;EVL;DNM2;ENKUR;INPP5D;DENND1A |
| integrin binding | FBLN1;DST;ICAM3;JAM3;CYR61;FERMT3;THBS1;P4HB;TNN |
| interleukin-6 receptor binding | ADAM17;PYCARD;ERAP1;IL6;CNTF |
| metalloendopeptidase activity | ADAM30;UQCRC1;ADAM32;ADAMTS2;HE1A;MMP19;ADAMTS16;MMP14A;MMP14B |
| metallopeptidase activity | ADAM10;STAMBPA;ERMP1;STAMBP;TAF2;TMEM27;Adamts19;ADAMTS1;AGBL1 |
| protein binding | MLPH;GPATCH8;CLPX;MEIS1B;RAB22A;RFX1;DCUN1D5;HIST1H2AK;MAT2A |
| zinc ion binding | NANOS1;DTNBA;S100A12;MT1A;ZRANB3;TAF15;CCNB1IP1;TRIM22;LHX6 |
ADAM17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM17 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM17.
DLG1; MAD2L1; APP; ITGB1; PDIA3; JAG1; TGFA; PTPN3; thiF; Sgol2
Research Area
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Customer Reviews (3)
Write a reviewCheap price, high quality products, worth buying again
The high quality of the purchased protein helped me to obtain satisfactory experimental results.
Good after-sales service attitude, helped me solve a lot of problems in the experiment.
Q&As (10)
Ask a questionADAM17 is a negative regulator of the RAS system.
Yes, we have produced ADAM17 protein of this purity.
ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.
ADAM17 is widely expressed in somatic and immune cells
ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.
ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.
The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.
Yes, ADAM17 protein is involved in this promotion.
ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.
Addition of His tags usually does not affect the function, properties of the target protein.
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