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Official Full Name ADAM metallopeptidase domain 17
Background This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Synonyms ADAM17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; ADAM18; CD156B; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAM17-26135TH Recombinant Human ADAM17 Wheat Germ N/A
    Human ADAM17-278H Recombinant Human ADAM17 Protein, GST-tagged Wheat Germ GST
    Human ADAM17-592H Recombinant Human ADAM Metallopeptidase Domain 17, His-tagged Insect Cell His
    Human ADAM17-593H Recombinant Human ADAM17 Insect Cell N/A
    Human ADAM17-7114H Recombinant Human ADAM17 protein, His-tagged E.coli His
    Mouse Adam17-256M Recombinant Mouse Adam17 protein, His-tagged HEK293 His
    Mouse Adam17-522M Recombinant Mouse A Disintegrin And Metallopeptidase Domain 17, His-tagged NS0 His
    Rat ADAM17-1198RCL Recombinant Rat ADAM17 cell lysate Human Cell N/A
    Rat ADAM17-501R Recombinant Rat ADAM17 Protein Mammalian Cell His
    Rat Adam17-7115R Recombinant Rat Adam17 protein, His & T7-tagged E.coli His/T7
    Rat Adam17-8788R Recombinant Rat Adam17, His tagged Human Cell His
    Chicken ADAM17-1867C Recombinant Chicken ADAM17 Mammalian Cell His
    Kit-0048 ADAM17 fluorometric drug discovery Kit N/A
    Kit-0049 ADAM17 Inhibitor Screening Assay Kit N/A

    adam17 involved in several pathways and played different roles in them. We selected most pathways adam17 participated on our site, such as Notch signaling pathway, Alzheimers disease, Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with adam17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Notch signaling pathway HER15.1; JAG2B; ADAM17; CTBP1; APH1C; KAT2A; NOTCH2; DTX3L; DVL3A; NCOR2
    Alzheimers disease ATP5F1; MAPK1; CALM3; NDUFA8; COX7B; COX7B2; PLCB2; NCSTN; IL1B; CASP12
    Epithelial cell signaling in Helicobacter pylori infection ATP6V1G2; ATP6V0D1; PLCG2; ATP6V1B1; CXCL1; TCIRG1; ATP6V1D; ATP6V1F; ATP6V1G3; MAPK13

    adam17 has several biochemical functions, for example, Notch binding, PDZ domain binding, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by adam17 itself. We selected most functions adam17 had, and list some proteins which have the same functions with adam17. You can find most of the proteins on our site.

    Function Related Protein
    Notch binding DNER; JAG1B; DLL1; JAG2B; NCOR2; DTX1; DLL3; CHAC1; AAK1; NOTCH4
    PDZ domain binding SLC9A3R1; DLC; NLGN1; SLC22A5; ATP2B3A; LPAR1; CXXC4; ARHGEF16; NSF; FZD7
    SH3 domain binding NOXA1; MVB12A; DRD4; FUT8; ARHGAP6; SH3BP5LA; REPS1; PDE4D; ABL1; FAM125A
    integrin binding ADAMTS8; SEMA7A; FBLN1; TNN; ADAM9; CTGFA; FBN1; ITGB1; ANGPTL3; SYK
    interleukin-6 receptor binding ERAP1; ADAM17; CNTF; IL6; PYCARD
    metalloendopeptidase activity YBEY; IDE; ADAM2; ADAM21; MEP1A.2; BMP1; MMP7; ADAM5P; ADAM10; ADAMTSL5
    metallopeptidase activity TMEM27; ADAM28; HE1A; GM12824; PAPPAB; ADAM9; AGBL4; ADAMTS5; CLCA1; PSMD14
    protein binding CDK18; DZIP1; C1orf51; LIN7A; OSTB; PCMT1; RASA1; CST3; CXCL9; NXF2
    zinc ion binding MMP13A; KIAA0913; SEC23A; MORC3; TRAF4B; TRIM35-21; PRKCA; KDM2AA; CLIP1; PPARAA

    adam17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adam17 here. Most of them are supplied by our site. Hope this information will be useful for your research of adam17.

    DLG1; MAD2L1; APP; ITGB1; PDIA3; JAG1; TGFA; PTPN3; thiF; Sgol2

    Li, GR; Forest, F; et al. A novel marker ADAM 17 for clear cell renal cell carcinomas: Implication for patients' prognosis. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32:1272-1276(2014).
    Arenaccio, C; Chiozzini, C; et al. Exosomes from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License Quiescent CD4(+) T Lymphocytes To Replicate HIV-1 through a Nef- and ADAM17-Dependent Mechanism. JOURNAL OF VIROLOGY 88:11529-11539(2014).

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