Recombinant Human ADAM Metallopeptidase Domain 17, His-tagged
Cat.No. : | ADAM17-592H |
Product Overview : | Recombinant human glycosylated catalytic domain (aa Pro1-Val477) of ADAM17/TACE secreted as mature, active enzyme frominsect cells,and purified using a C-terminal His-tag, 36kDa. |
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Cat. No. : | ADAM17-592H |
Description : | ADAM17/TACE is a soluble or membrane-bound metalloproteinase primarily responsible for activation of proTNF-α, while also targeting proteins such as fractalkine, amyloid precursor proteins, and CD40. ADAM17/TACE is involved in cancer, vascular disorders, and inflammatory diseases such as rheumatoid arthritis and focal ischemic injury. The catalytic domain of ADAM17/TACE is able to cleave proTNF-α and can be used in inhibitor screening. |
Source : | insect cells. |
Concentration : | 0.45 µg/µl. |
Purity : | ≥90% (SDS-PAGE). |
Formulation : | Liquid. In 22.5mM TRIS, pH 7.5, containing 4.5µM ZnCl2, 0.0045% Brij-35 and 10% glycerol. |
Specific Activity: : | 2'430 U/µg enzyme. One unit will hydrolyze one pmole Mca-PLAQAV-Dpa-RSSSR-NH2 substrate (10µM) per minute at 37°C, in 25mM TRIS, pH 9.0. |
Application : | Study enzyme kinetics, cleave target substrates, screen inhibitors. |
Storage : | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. |
Pathways : | Alzheimer"s disease; Epithelial cell signaling in Helicobacter pylori infection; Notch signaling pathway; Signaling by EGFR; Signalling by NGF |
Protein length : | Pro1-Val477 |
Gene Name : | ADAM17 ADAM metallopeptidase domain 17 [ Homo sapiens ] |
Synonyms : | ADAM metallopeptidase domain 17; CSVP; TACE; ADAM18; CD156B; MGC71942; ADAM17; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; EC 3.4.24.86; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; ADAM metallopeptidase domain 18;tumor necrosis factor, alpha, converting enzyme; a disintegrin and metalloprotease domain 17; CD156b antigen |
Gene ID : | 6668 |
mRNA Refseq : | NM_003183 |
Protein Refseq : | NP_003174 |
MIM : | 603639 |
UniProt ID : | P78536 |
Chromosome Location : | 2p25 |
Function : | PDZ domain binding; SH3 domain binding; integrin binding; interleukin-6 receptor binding; metal ion binding; metalloendopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewCheap price, high quality products, worth buying again
The high quality of the purchased protein helped me to obtain satisfactory experimental results.
Good after-sales service attitude, helped me solve a lot of problems in the experiment.
Q&As (10)
Ask a questionADAM17 is a negative regulator of the RAS system.
Yes, we have produced ADAM17 protein of this purity.
ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.
ADAM17 is widely expressed in somatic and immune cells
ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.
ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.
The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.
Yes, ADAM17 protein is involved in this promotion.
ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.
Addition of His tags usually does not affect the function, properties of the target protein.
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