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Recombinant Full Length Human Disintegrin And Metalloproteinase Domain-Containing Protein 17(Adam17) Protein, His-Tagged

Cat.No. : RFL-25931HF
Product Overview : Recombinant Full Length Human Disintegrin and metalloproteinase domain-containing protein 17(ADAM17) Protein (P78536) (215-824aa), fused to N-terminal His tag, was expressed in E. coli.
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Source : E.coli expression system
Species : Homo sapiens (Human)
Tag : His
Form : Lyophilized powder
Protein length : Full Length of Mature Protein (215-824)
AA Sequence : RADPDPMKNTCKLLVVADHRFYRYM GRGEESTTTNYLIELIDRVDDIYRN TSWDNAGFKGYGIQIEQIRILKSPQ EVKPGEKHYNMAKSYPNEEKDAWDV KMLLEQFSFDIAEEASKVCLAHLFT YQDFDMGTLGLAYVGSPRANSHGGV CPKAYYSPVGKKNIYLNSGLTSTKN YGKTILTKEADLVTTHELGHNFGAE HDPDGLAECAPNEDQGGKYVMYPIA VSGDHENNKMFSNCSKQSIYKTIES KAQECFQERSNKVCGNSRVDEGEEC DPGIMYLNNDTCCNSDCTLKEGVQC SDRNSPCCKNCQFETAQKKCQEAIN ATCKGVSYCTGNSSECPPPGNAEDD TVCLDLGKCKDGKCIPFCEREQQLE SCACNETDNSCKVCCRDLSGRCVPY VDAEQKNLFLRKGKPCTVGFCDMNG KCEKRVQDVIERFWDFIDQLSINTF GKFLADNIVGSVLVFSLIFWIPFSI LVHCVDKKLDKQYESLSLFHPSNVE MLSSMDSASVRIIKPFPAPQTPGRL QPAPVIPSAPAAPKLDHQRMDTIQE DPSTDSHMDEDGFEKDPFPNSSTAA KSFEDLTDHPVTRSEKAASFKLQRQ NRVDSKETEC
Purity : Greater than 90% as determined by SDS-PAGE.
Applications : SDS-PAGE
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Storage Buffer : Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Gene Name : ADAM17
Synonyms : ADAM17; CSVP; TACE; Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD antigen CD156b
UniProt ID : P78536
Gene Name : ADAM17
Synonyms : ADAM17; CSVP; TACE; Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD antigen CD156b
UniProt ID : P78536

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
04/08/2022

    Cheap price, high quality products, worth buying again

    03/15/2019

      The high quality of the purchased protein helped me to obtain satisfactory experimental results.

      02/26/2019

        Good after-sales service attitude, helped me solve a lot of problems in the experiment.

        Q&As (10)

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        Is ADAM17 protein involved in the renin-angiotensin system? 08/01/2022

        ADAM17 is a negative regulator of the RAS system.

        My research requires high protein purity, can I customize > 90% ADAM17 protein? 06/05/2022

        Yes, we have produced ADAM17 protein of this purity.

        What proteins does ADAM17 cleave? 04/07/2022

        ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.

        Where ADAM17 is highly expressed? 06/25/2021

        ADAM17 is widely expressed in somatic and immune cells

        In addition to Diabetes mellitus and cardiomyopathy-related research, ADAM17 is currently used in the research of which diseases? 01/21/2021

        ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.

        Is ADAM17 associated with the EGFR-PI3K-AKT pathway? 10/03/2020

        ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.

        Does the package insert for ADAM17 contain detailed information on the handling of the lyophilized powder product? 04/19/2020

        The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.

        ADAM17 protein is also involved in recent activities? 12/11/2019

        Yes, ADAM17 protein is involved in this promotion.

        Does ADAM17 mediate the Notch pathway? 10/05/2019

        ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.

        Does adding His tag have any effect on protein? 04/24/2019

        Addition of His tags usually does not affect the function, properties of the target protein.

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