Recombinant Human FASTK (Active), GST-tagged FASTK-1402H

Cat.No.:	FASTK-1402H
Product Overview:	Recombinant full-length human FASTK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description:	FASTK or Fas-Activated Serine/Threonine Kinase is a member of the serine/threonine protein kinase family that becomes rapidly activated during Fas-mediated apoptosis in Jurkat cells and in response to Fas receptor ligation. FASTK interacts with and phosphorylates TIA1 which is an apoptosis-promoting nuclear RNA-binding protein. FAST K influences alternative pre-mRNA splicing by affecting the activity of TIA-1/TIAR. FASTK is a strong inducer of lymphocyte apoptosis. FASTK is the component of the molecular cascade that involved in FAS-mediated apoptosis. FASTK is highly expreesed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Source:	Sf9 Cells
Species:	Human
Tag:	GST
Form:	Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity:	1.0 nmol/min/mg
Molecular Mass:	~84 kDa
Protein length:	Full length
Purity:	>70%
Applications:	Kinase Assay, Western Blot
Storage:	Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration:	0.1μg/μl

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Gene Name:	FASTK Fas-activated serine/threonine kinase [ Homo sapiens ]
Official Symbol:	FASTK
Synonyms:	FASTK; Fas-activated serine/threonine kinase; fas-activated serine/threonine kinase; FAST; FAST kinase;
Gene ID:	10922
mRNA Refseq:	NM_006712
Protein Refseq:	NP_006703
MIM:	606965
UniProt ID:	Q14296
Chromosome Location:	7q35
Function:	ATP binding; Fas-activated serine/threonine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity;