Recombinant Human PDE6C, GST-tagged

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Recombinant Human PDE6C, GST-tagged

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Cat.No. : PDE6C-7011H
Product Overview : Recombinant full-length human PDE6C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : PDE6C or phosphodiesterase 6C, cGMP-specific, cone, alpha prime encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. PDE6C protein consists of 22 exons spanning approximately 48 kb of genomic DNA. The intron-exon structure of human PDE6C is very similar to that of rod PDE6B. A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene and mutations in PDE6C are associated with cone dystrophy type 4 (COD4).
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~125 kDa
Protein length : Full length
Purity : >75%
Applications : Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1 μg/μl
Gene Name : PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime [ Homo sapiens ]
Official Symbol : PDE6C
Synonyms : PDE6C; phosphodiesterase 6C, cGMP-specific, cone, alpha prime; cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha; PDEA2; cGMP phosphodiesterase 6C; COD4;
Gene ID : 5146
mRNA Refseq : NM_006204
Protein Refseq : NP_006195
MIM : 600827
UniProt ID : P51160
Chromosome Location : 10q24
Pathway : Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Visual signal transduction: Cones, organism-specific biosystem;
Function : 3,5-cyclic-GMP phosphodiesterase activity; cGMP binding; hydrolase activity; metal ion binding; nucleotide binding; phosphoric diester hydrolase activity;

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