Recombinant Human PDE6C, GST-tagged PDE6C-7011H

Recombinant Human PDE6C, GST-tagged


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Cat.No. : PDE6C-7011H Optional Service: Optional requirements on this protein
Product Overview : Recombinant full-length human PDE6C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : PDE6C or phosphodiesterase 6C, cGMP-specific, cone, alpha prime encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. PDE6C protein consists of 22 exons spanning approximately 48 kb of genomic DNA. The intron-exon structure of human PDE6C is very similar to that of rod PDE6B. A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene and mutations in PDE6C are associated with cone dystrophy type 4 (COD4).
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~125 kDa
Protein length : Full length
Purity : >75%
Applications : Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1 μg/μl
Gene Name : PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime [ Homo sapiens ]
Official Symbol : PDE6C
Synonyms : PDE6C; phosphodiesterase 6C, cGMP-specific, cone, alpha prime; cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha; PDEA2; cGMP phosphodiesterase 6C; COD4;
Gene ID : 5146
mRNA Refseq : NM_006204
Protein Refseq : NP_006195
MIM : 600827
UniProt ID : P51160
Chromosome Location : 10q24
Pathway : Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Visual signal transduction: Cones, organism-specific biosystem;
Function : 3,5-cyclic-GMP phosphodiesterase activity; cGMP binding; hydrolase activity; metal ion binding; nucleotide binding; phosphoric diester hydrolase activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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