Recombinant Human PDE6C protein, GST-tagged
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Cat.No. : | PDE6C-444H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human PDE6C fused with GST tag at N-terminal was expressed in Insect cells. |
Description : | PDE6C or phosphodiesterase 6C, cGMP-specific, cone, alpha prime encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. PDE6C protein consists of 22 exons spanning approximately 48 kb of genomic DNA. The intron-exon structure of human PDE6C is very similar to that of rod PDE6B. A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene and mutations in PDE6C are associated with cone dystrophy type 4 (COD4). |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~125 kDa |
Purity : | > 75% |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 ug/uL |
Gene Name : | PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime [ Homo sapiens ] |
Official Symbol : | PDE6C |
Synonyms : | PDE6C; phosphodiesterase 6C, cGMP-specific, cone, alpha prime; cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha; PDEA2; cGMP phosphodiesterase 6C; COD4; |
Gene ID : | 5146 |
mRNA Refseq : | NM_006204 |
Protein Refseq : | NP_006195 |
MIM : | 600827 |
UniProt ID : | P51160 |
Chromosome Location : | 10q24 |
Pathway : | Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Visual signal transduction: Cones, organism-specific biosystem; |
Function : | 3,5-cyclic-GMP phosphodiesterase activity; cGMP binding; hydrolase activity; metal ion binding; nucleotide binding; phosphoric diester hydrolase activity; |
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Pde10aPDE11APDE1APDE1BPde1cPDE2APDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE6BPDE6CPDE6DPDE7APDE7BPDE8APDE9APDE4DIPPDE12PDE6APDE8BPDE6GPDE6H
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