Recombinant Human GDF15, His-tagged

• Cat.No.: GDF15-28170TH

Specification

• Cat. No.: GDF15-28170TH
• ProductOverview: Recombinant full length human GDF15 with His tag; amino acids 195-308, 16.7kDa.
• Description: Growth differentiation factor 15 (GDF15), also known as MIC-1, PDF, PLAB, and PTGFB, is a member of the transforming growth factor β (TGFβ) superfamily. It plays an important role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. This protein is synthesized intracellularly and secreted as a dimer linked by disulfide bonds. GDF15 is widely expressed in adult tissue with most abundant level in the liver, and its expression in liver can be significantly upregulated during injury of organs such as liver, kidney, heart and lung. In the brain, GDF15 expression occurs in the choroid plexus, from which the protein is secreted into the cerebrospinal fluid. As a responsive gene for p53 tumor suppressor protein, the encoded GDF15 protein can prevent cell death by the activation of Akt and inhibition of ERK, and overexpression of GDF15 occurs in certain carcinomas.GDF15 acts as a trophic factor for certain classes of neurons, promoting cell survival and differentiation. Additionally, GDF15 has been identified as a bone marrow-derived factor that abrogates hepcidin-mediated protection from iron overload under conditions of increased erythropoiesis.
• Conjugation: His
• Source: E. coli
• Tissue specificity: Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 10mM Sodium citrate, pH 3.5
• Storage: Shipped at 4oC. Upon delivery aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
• SequenceSimilarities: Belongs to the TGF-beta family.

Gene Information

• Gene Name: GDF15 growth differentiation factor 15 [ Homo sapiens ]
• Synonyms: GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1;NAG-1; PTGFB; GDF-15; PTGF-beta; prostate differentiation factor; NSAID(nonsteroidal anti-inflammatory drug)-activatedprotein 1; NRG-1; Macrophage inhibitory cytokine 1; NSAID-activated gene1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placentalbone morphogeneticprotein; Growth/differentiation factor 15
• Gene ID: 9518
• mRNA Refseq: NM_004864
• Protein Refseq: NP_004855
• MIM: 605312
• UniProt ID: Q99988
• Chromosome Location: 19p13.11
• Function: cytokine activity; growth factor activity