GDF15

  • Official Full Name

    growth differentiation factor 15

  • Overview

    Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]
  • Synonyms

    GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • Rhesus monkey
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293F
  • Human
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Avi
  • Fc
  • C
  • His
  • GST
  • His (Fc)
  • N/A
  • N
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GDF15-246H Active Recombinant Human GDF15 protein E.coli N/A
Human GDF15-268H Active Recombinant Human GDF15 E.coli N/A
Human GDF15-27680TH Active Native Human GDF15 Protein N/A
Human GDF15-243H Recombinant Human Growth Differentiation Factor 15 N/A
Human GDF15-28170TH Recombinant Human GDF15, His-tagged E.coli His
Human GDF15-204H Recombinant Human GDF15 protein(Ala197-Ile308), hFc-tagged HEK293 N-hFc
Human GDF15-337H Recombinant Human Growth Differentiation Factor 15 CHO N/A
Human GDF15-20H Recombinant Human GDF15 protein(Ala197-Ile308), His-tagged Yeast N-His
Human GDF15-362H Recombinant Human Growth Differentiation Factor 15 E.coli N/A
Human GDF15-626H Recombinant Human Growth Differentiation Factor 15, His-tagged Human His
Human GDF15-2705HCL Recombinant Human GDF15 cell lysate Human Cell N/A
Human GDF15-338H Recombinant Human GDF15 Protein, His tagged E.coli N-His
Human GDF15-4821H Active Recombinant Human GDF15 Protein CHO N/A
Human GDF15-284H Recombinant Human GDF15 protein, His-tagged E.coli His
Human GDF15-1484H Active Recombinant Human GDF15 protein, Fc-tagged HEK293 Fc
Human GDF15-047H Recombinant Human GDF15 Protein E. coli
Human GDF15-285H Recombinant Human GDF15 protein, His-tagged E.coli His
Human GDF15-4755H Recombinant Human GDF15 protein, His-tagged E.coli His
Human GDF15-4822H Recombinant Human GDF15 Protein, GST-tagged Wheat Germ GST
Human GDF15-105H Active Recombinant Human GDF15 Protein E.coli
Human GDF15-946H Recombinant Human GDF15 Protein, His-tagged HEK293F N-His
Human GDF15-4754H Recombinant Human GDF15 protein, His-tagged E.coli His
Human GDF15-5232HF Recombinant Full Length Human GDF15 Protein, GST-tagged In Vitro Cell Free System GST
Human GDF15-17H Recombinant Human GDF15 Protein E.coli
Human GDF15-106H Active Recombinant Human GDF15 Protein E.coli
Human GDF15-1855H Active Recombinant Human GDF15 protein, Avi & Fc-tagged, Biotinylated HEK293 Avi & Fc
Human GDF15-0067H Recombinant Human GDF15 Protein HEK293 cells
Human GDF15-3309H Recombinant Human GDF15 Protein (Ala197-Ile308), His tagged E.coli His
Mouse Gdf15-393M Active Recombinant Mouse Gdf15 protein E.coli N/A
Mouse Gdf15-392M Recombinant Mouse Gdf15 protein, His-tagged E.coli His
Mouse Gdf15-26M Recombinant Mouse Gdf15 protein, His-tagged E.coli His
Mouse GDF15-6285M Recombinant Mouse Gdf15 protein, His-tagged HEK293 His
Mouse Gdf15-5783M Recombinant Mouse Gdf15 Protein (Trp31-Ala303), C-His tagged Mammalian cells C-His
Mouse Gdf15-7379M Recombinant Mouse Gdf15 Protein, His-tagged E.coli His
Mouse Gdf15-01M Active Recombinant Mouse Gdf15 Protein, Fc-tagged HEK293 Fc
Rat Gdf15-26R Recombinant Rat Gdf15 Protein, His-tagged E.coli His
Rat GDF15-2502R Recombinant Rat GDF15 Protein Mammalian Cell His
Rat GDF15-2158R Recombinant Rat GDF15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GDF15-2158R-B Recombinant Rat GDF15 Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey GDF15-1277R Recombinant Rhesus monkey GDF15 protein, His-tagged E.coli His
Cynomolgus GDF15-1483C Active Recombinant Cynomolgus GDF15 protein, His-tagged E.coli His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GDF15 Related Articles
  • GDF15 Related Gene Family
  • GDF15 Related Research Area

GDF15 involved in several pathways and played different roles in them. We selected most pathways GDF15 participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Direct p53 effectorsEDN2;ARID3A;CTSD;RNF144B;CEBPZ;EPHA2;AIFM2;CCNK;FDXR

GDF15 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF15 itself. We selected most functions GDF15 had, and list some proteins which have the same functions with GDF15. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIFNA4;TNFB;CXCL9;Il23a; Il12b;IL18;TNFSF11;IL32;CTF1;Il1f6
growth factor activityFGF5;CLEC11A;GDF6B;IL8L2;GPI1;GDF6;GDF1;NTF3;FGF13B
transforming growth factor beta receptor bindingGDF1;NDR2;TGFBRAP1;GDF15;MSTNA;INHBE;SPAW;BMP7;LFT1

GDF15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF15 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF15.

MDFI; MAPK14; Trip11; ssrna_a; STAT5A; Smn1; Cdc37; MRPL50; NUPL1; SETD4; SAE1

von der Heyde, S; Wagner, S; et al. mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer. PLOS ONE 10:-(2015).
Hinoi, E; et al. Regulation of Osteoclastogenesis by Osteocytes through Growth Differentiation Factor-15. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 134:1259-1263(2014).
TGF
  • Q&As
  • Reviews

Q&As (7)

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What role does GDF15 play in cardiovascular diseases, particularly in heart failure and atherosclerosis? 08/14/2022

GDF15 influences cardiovascular health, impacting heart failure progression and atherosclerotic processes.

How does GDF15 influence inflammatory processes and immune responses in chronic diseases? 07/17/2022

GDF15 modulates inflammatory and immune responses, crucial in the context of chronic diseases.

How does GDF15 contribute to tissue repair and fibrosis in organs like the liver and kidneys? 10/16/2021

GDF15 contributes to tissue repair and fibrosis, particularly in liver and kidney pathologies.

What is the impact of GDF15 on cancer development and progression, especially in terms of tumor microenvironment modulation? 05/18/2021

GDF15 affects cancer development by altering the tumor microenvironment and influencing tumor cell behavior.

How do alterations in GDF15 expression impact aging and age-related pathologies? 07/14/2018

Changes in GDF15 expression are linked to aging and age-related diseases, affecting various physiological processes.

How does GDF15 regulate energy metabolism and appetite in the context of obesity and metabolic disorders? 04/21/2018

GDF15 is involved in regulating energy metabolism and appetite, playing a key role in obesity and metabolic syndromes.

What are the mechanisms by which GDF15 affects cellular stress responses and apoptosis? 03/05/2018

GDF15 is involved in cellular stress responses, influencing apoptosis and cell survival mechanisms.

Customer Reviews (3)

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Reviews
03/19/2021

    Dependable protein purification, consistent and cost-effective.

    07/29/2019

      Precise mass spectrometry analysis, key for proteomics research.

      02/22/2019

        Great antibody validation, enhances our immunoprecipitation experiments.

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