Recombinant Human Growth Differentiation Factor 15

• Cat.No.: GDF15-243H
• Product Overview: Recombinant Human GDF-15/MIC-1 produced inCell cultureis a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains.

Specification

• Cat. No.: GDF15-243H
• Description: GDF-15 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
• Source: Cell culture.
• Purity: 98 % (SDS-PAGE, HPLC).
• Endotoxin level: < 0.1 ng per μg of GDF-15/MIC-1.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biologically Activity: Determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1.0-2.0 μg/ml.
• Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted GDF-15/MIC-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: GDF15 growth differentiation factor 15 [ Homo sapiens ]
• Synonyms: GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1;NAG-1; PTGFB; GDF-15; PTGF-beta; prostate differentiation factor; NSAID(nonsteroidal anti-inflammatory drug)-activatedprotein 1; NRG-1; Macrophage inhibitory cytokine 1; NSAID-activated gene1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placentalbone morphogeneticprotein;Growth/differentiation factor 15
• Gene ID: 9518
• mRNA Refseq: NM_004864
• Protein Refseq: NP_004855
• MIM: 605312
• UniProt ID: Q99988
• Chromosome Location: 19p13.11
• Function: cytokine activity; growth factor activity