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Recombinant Human Interleukin 15
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| Cat. No. : | IL15-483H |
| Product Overview : | Recombinant human IL-15 produced in E.coli is a single, non-glycosylated polypeptide chain containing 114 amino acids and having a molecular mass of 12,773.5 Daltons. |
| Description : | Interleukin 15 (IL-15) is a pleiotropic pro-inflammatory cytokine that promotes activation of T cells, neutrophils and macrophages, and is critical to dendritic cell function in several model systems. IL-15 has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes. |
| Species : | Human |
| Source : | E.coli |
| Form : | Recombinant IL-15 was lyophilized from a concentrated (1mg/ml) solution with 5mM Tris pH 8.0. |
| Purity : | Purity Greater than 98% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE. |
| Bio-activity : | Recombinant IL-15 is fully biologically active when compared to standards. The ED50, as determined by the dose-dependant stimulation of the proliferation of mouse CTLL-2 cells, was found to be < 0.5 ng/ml. |
| Physical Appearance : | Sterile Filtered white lyophilized (freeze-dried) powder. |
| Solubility : | It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions. |
| Purity Greater than 98% as determined by : | Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE. |
| Protein Content determined by : | UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard. |
| Endotoxin Level : | Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug. |
| Amino acid sequence : | MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS |
| Storage : | Lyophilized product is very stable at -20 °C. Reconstituted material should be aliquoted and frozen at -20°C. It is recommended that a carrier protein (0.1% HSA or BSA) is added to the sample for long term storage. |
| Pathways : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway |
| Renderingbased on PDB 2Z3Q. : |
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| Gene Name : | IL15 interleukin 15 [ Homo sapiens ] |
| Official Symbol : | IL15 |
| Synonyms : | IL15; interleukin 15; IL-15; MGC9721; OTTHUMP00000164617 |
| Gene ID : | 3600 |
| mRNA Refseq : | NM_000585 |
| Protein Refseq : | NP_000576 |
| MIM : | 600554 |
| UniProt ID : | P40933 |
| Chromosome Location : | 4q31 |
| Function : | cytokine activity; cytokine receptor binding; protein binding; signal transducer activity |
◆ Recombinant Protein
| Il15-091M | Recombinant Mouse Il15 Protein | +Inquiry |
| IL15-004H | Recombinant Human IL15 Protein, His-tagged | +Inquiry |
| IL15-382H | Recombinant Human IL15 Protein (Asn49-Ser162) | +Inquiry |
| IL15-01R | Recombinant Rhesus Monkey IL15 Protein, His-tagged | +Inquiry |
| Il15-092M | Recombinant Mouse Il15 Protein, MYC/DDK-tagged | +Inquiry |
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◆ Lysates
| IL15-5248HCL | Recombinant Human IL15 293 Cell Lysate | +Inquiry |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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