"IL1RL1" Related Products

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Recombinant Human Interleukin 1 Receptor-Like 1, His-tagged

Cat. No.: IL1RL1-396H
Product Overview: IL1RL1 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 310 amino acids fragment (19-328) corresponding to the soluble IL1RL1 coding sequence, having a molecular weight of 36kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The IL1RL1 is purified by proprietary chromatographic techniques.
Description: The IL1RL1 gene is a member of the IL-1 receptor family, encoding a transmembrane protein with a structure similar to IL-1R1. IL1RL1 is a receptor for interleukin-33, its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 may possibly be involved in helper T-cell function. IL1RL1 is highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. A soluble form of the IL1RL1 is produced from the same gene by alternative splicing and was shown to be expressed in several cell types including fibroblasts and mast cells. Soluble IL1RL1 also acts as a negative regulator of Th2 cytokine production and high levels have been reported in several disease states and conditions including asthma, sepsis and myocardial infarction. Analysis of the similar gene in mouse suggested that the IL1RL1 receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells.
Source: Human
Host: Escherichia Coli.
Form: IL1RL1 protein is supplied in 1xPBS, 50% glycerol.
Purity: Greater than 95.0% as determined by SDS-PAGE.
Physical Appearance: Sterile Filtered clear solution.
Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name: IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ]
Official Symbol: IL1RL1
Synonyms: IL1RL1; interleukin 1 receptor-like 1; T1; ST2; DER4; ST2L; ST2V; FIT-1; MGC32623; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; nterleukin-1 receptor-like 1; Protein ST2; OTTHUMP00000161342
Gene ID: 9173
mRNA Refseq: NM_003856
Protein Refseq: NP_003847
MIM: 601203
UniProt ID: Q01638
Chromosome Location: 2q12
Function: interleukin-1 receptor activity; interleukin-33 receptor activity; protein binding; receptor signaling protein activity

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