Active Recombinant Human Platelet Factor 4
Cat.No. : | PF4-194H |
Product Overview : | A DNA sequence encoding the human CXCL4 ( NP_002610.1 ) ( Glu 32 - Ser 101 ) was expressed |
- Specification
- Gene Information
- Related Products
Cat. No. : | PF4-194H |
Description : | Platelet factor 4 ( PF4 ) is a 70-amino acid protein belonging to the CXC chemokine family also known as chemokine ( C-X-C motif ) ligand 4 ( CXCL4 ) . Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. PF4 is the antigen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. Its autoantibodies have been found in patients with thrombosis and features resembling HIT but no prior administration of heparin. |
Source : | Human |
Host : | E.coli |
Form : | Lyophilized from sterile PBS , pH 7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. |
Purity : | > 97 % as determined by SDS-PAGE |
Bio-activity : | The ED50 for this effect is typically 4.2 μg/mL; The EC50 of biotinylated human VEGF165 is 9.97 μg/mL |
Endotoxin : | ﹤1.0 EU per μg protein as determined by the LAL method |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 μ |
Predicted N terminal : | Met |
Molecular Mass : | The recombinant human CXCL4 comprises 71 amino acids with a predicted molecular mass of 7.8 kDa as estimated in SDS-PAGE under reducing conditions |
Storage : | Store it under sterile conditions at -70μ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | PF4 platelet factor 4 [ Homo sapiens ] |
Official Symbol : | PF4 |
Synonyms : | PF4; platelet factor 4; chemokine (C-X-C motif) ligand 4; CXCL4; iroplact ; SCYB4; oncostatin-A; Oncostatin-A; PF-4; Iroplact ; C-X-C motif chemokine 4; Oncostatin-A; MGC138298; Platelet factor 4; OTTHUMP00000160478 |
Gene ID : | 5196 |
mRNA Refseq : | NM_002619 |
Protein Refseq : | NP_002610 |
MIM : | 173460 |
UniProt ID : | P02776 |
Chromosome Location : | 4q12-q21 |
Pathway : | Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Hemostasis; Signaling by GPCR |
Function : | chemokine activity; heparin binding |
Products Types
◆ Recombinant Protein | ||
PF4-245H | Active Recombinant Human PF4 Protein (Glu32-Ser101), N-His tagged, Animal-free, Carrier-free | +Inquiry |
PF4-166P | Active Recombinant Human PF4 Protein | +Inquiry |
PF4-4048R | Recombinant Rat PF4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Pf4-4802M | Active Recombinant Mouse Pf4 Protein | +Inquiry |
PF4-1181H | Recombinant Horse PF4 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
PF4-253H | Native Human Platelet Factor 4 | +Inquiry |
◆ Lysates | ||
PF4-3283HCL | Recombinant Human PF4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionSome research has explored the development of antibodies targeting PF4 to mitigate its pro-inflammatory effects, although such treatments are still in the early stages of investigation.
PF4 can promote inflammation by recruiting and activating immune cells, such as monocytes and neutrophils, at the site of inflammation.
Management often involves discontinuing heparin and initiating alternative anticoagulation strategies, such as direct thrombin inhibitors or fondaparinux.
Yes, elevated PF4 levels have been associated with various inflammatory states, making it a potential biomarker for certain diseases.
ELISA (enzyme-linked immunosorbent assay) is commonly used to detect anti-PF4/heparin antibodies in patients suspected of having HIT.
Customer Reviews (3)
Write a reviewthe PF4 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.
Its impeccable purity and reliability ensure accurate and reproducible results, providing a solid foundation for my research.
he PF4 protein is an exceptional choice that meets the highest standards of quality, perfectly catering to my experimental requirements.
Ask a Question for All PF4 Products
Required fields are marked with *
My Review for All PF4 Products
Required fields are marked with *
Inquiry Basket