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Active Recombinant Human Platelet Factor 4

Cat.No. : PF4-194H
Product Overview : A DNA sequence encoding the human CXCL4 ( NP_002610.1 ) ( Glu 32 - Ser 101 ) was expressed
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Cat. No. : PF4-194H
Description : Platelet factor 4 ( PF4 ) is a 70-amino acid protein belonging to the CXC chemokine family also known as chemokine ( C-X-C motif ) ligand 4 ( CXCL4 ) . Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. PF4 is the antigen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. Its autoantibodies have been found in patients with thrombosis and features resembling HIT but no prior administration of heparin.
Source : Human
Host : E.coli
Form : Lyophilized from sterile PBS , pH 7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
Purity : > 97 % as determined by SDS-PAGE
Bio-activity : The ED50 for this effect is typically 4.2 μg/mL; The EC50 of biotinylated human VEGF165 is 9.97 μg/mL
Endotoxin : ﹤1.0 EU per μg protein as determined by the LAL method
Stability : Samples are stable for up to twelve months from date of receipt at -70 μ
Predicted N terminal : Met
Molecular Mass : The recombinant human CXCL4 comprises 71 amino acids with a predicted molecular mass of 7.8 kDa as estimated in SDS-PAGE under reducing conditions
Storage : Store it under sterile conditions at -70μ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : PF4 platelet factor 4 [ Homo sapiens ]
Official Symbol : PF4
Synonyms : PF4; platelet factor 4; chemokine (C-X-C motif) ligand 4; CXCL4; iroplact ; SCYB4; oncostatin-A; Oncostatin-A; PF-4; Iroplact ; C-X-C motif chemokine 4; Oncostatin-A; MGC138298; Platelet factor 4; OTTHUMP00000160478
Gene ID : 5196
mRNA Refseq : NM_002619
Protein Refseq : NP_002610
MIM : 173460
UniProt ID : P02776
Chromosome Location : 4q12-q21
Pathway : Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Hemostasis; Signaling by GPCR
Function : chemokine activity; heparin binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any therapeutic approaches targeting PF4 protein? 02/17/2023

Some research has explored the development of antibodies targeting PF4 to mitigate its pro-inflammatory effects, although such treatments are still in the early stages of investigation.

How does PF4 protein contribute to the pathogenesis of inflammation? 11/11/2022

PF4 can promote inflammation by recruiting and activating immune cells, such as monocytes and neutrophils, at the site of inflammation.

What are the potential treatment options for patients with HIT? 04/24/2017

Management often involves discontinuing heparin and initiating alternative anticoagulation strategies, such as direct thrombin inhibitors or fondaparinux.

Can PF4 protein be used as a biomarker for other conditions? 06/20/2016

Yes, elevated PF4 levels have been associated with various inflammatory states, making it a potential biomarker for certain diseases.

What diagnostic methods are used to assess PF4 protein levels? 01/30/2016

ELISA (enzyme-linked immunosorbent assay) is commonly used to detect anti-PF4/heparin antibodies in patients suspected of having HIT.

Customer Reviews (3)

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Reviews
09/07/2022

    the PF4 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.

    06/30/2018

      Its impeccable purity and reliability ensure accurate and reproducible results, providing a solid foundation for my research.

      12/12/2017

        he PF4 protein is an exceptional choice that meets the highest standards of quality, perfectly catering to my experimental requirements.

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