Expand Expand| Cat. No. : | CASP3-1642H |
| Product Overview : | Recombinant full-length human CASP3 containing was expressed in E. coli. |
| Description : | CASP3 (also know as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. CASP3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B. |
| Molecular Weight : | large (17 kD) and small (11 kD) subunits |
| Source : | E. coli |
| Species : | Human |
| Form : | Lyophilized powder. |
| Appearance : | Lyophilized powder |
| Reconstitution : | Reconstitute in PBS containing 15% glycerol. |
| Storage : | The lyophilized caspase-3 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease. |
| Pathways : | Activation of DNA fragmentation factor; Apoptosis; Amoebiasis; Alzheimer"s disease; Alpha6-Beta4 Integrin Signaling Pathway; Androgen Receptor Signaling Pathway; Apoptosis Modulation by HSP70; Apoptosis induced DNA fragmentation; Apoptotic cleavage of cellular proteins; Caspase cascade in apoptosis; Cell death signalling via NRAGE; Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; Herpes simplex infection; Huntington"s disease |
| Gene Name : | CASP3 caspase 3, apoptosis-related cysteine peptidase [ Homo sapiens ] |
| Official Symbol : | CASP3 |
| Synonyms : | CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; caspase-3; Yama; CASP-3; CPP-32; apopain; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine protease; Caspase-3; Apopain; Cysteine protease CPP32; Protein Yama; EC 3.4.22.56; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; OTTHUMP00000165055; OTTHUMP00000224230; OTTHUMP00000224231 |
| Gene ID : | 836 |
| mRNA Refseq : | NM_004346 |
| Protein Refseq : | NP_004337 |
| MIM : | 600636 |
| UniProt ID : | P42574 |
| Chromosome Location : | 4q34 |
| Function : | cysteine-type endopeptidase activity; peptidase activity; protein binding |
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