"CASP3" Related Products

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Recombinant Human Caspase 3, Apoptosis-related Cysteine Peptidase

Cat. No.: CASP3-1642H
Product Overview: Recombinant full-length human CASP3 containing was expressed in E. coli.
Description: CASP3 (also know as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. CASP3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B.
Molecular Weight: large (17 kD) and small (11 kD) subunits
Source: E. coli
Species: Human
Form: Lyophilized powder.
Appearance: Lyophilized powder
Reconstitution: Reconstitute in PBS containing 15% glycerol.
Storage: The lyophilized caspase-3 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease.
Pathways: Activation of DNA fragmentation factor; Apoptosis; Amoebiasis; Alzheimer"s disease; Alpha6-Beta4 Integrin Signaling Pathway; Androgen Receptor Signaling Pathway; Apoptosis Modulation by HSP70; Apoptosis induced DNA fragmentation; Apoptotic cleavage of cellular proteins; Caspase cascade in apoptosis; Cell death signalling via NRAGE; Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; Herpes simplex infection; Huntington"s disease
Gene Name: CASP3 caspase 3, apoptosis-related cysteine peptidase [ Homo sapiens ]
Official Symbol: CASP3
Synonyms: CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; caspase-3; Yama; CASP-3; CPP-32; apopain; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine protease; Caspase-3; Apopain; Cysteine protease CPP32; Protein Yama; EC 3.4.22.56; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; OTTHUMP00000165055; OTTHUMP00000224230; OTTHUMP00000224231
Gene ID: 836
mRNA Refseq: NM_004346
Protein Refseq: NP_004337
MIM: 600636
UniProt ID: P42574
Chromosome Location: 4q34
Function: cysteine-type endopeptidase activity; peptidase activity; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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