Cat. No. : |
CASP3-1642H |
Product Overview : |
Recombinant full-length human CASP3 containing was expressed in E. coli. |
Description : |
CASP3 (also know as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. CASP3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B. |
Molecular Weight : |
large (17 kD) and small (11 kD) subunits |
Source : |
E. coli |
Species : |
Human |
Form : |
Lyophilized powder. |
Appearance : |
Lyophilized powder |
Reconstitution : |
Reconstitute in PBS containing 15% glycerol. |
Storage : |
The lyophilized caspase-3 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease. |
Pathways : |
Activation of DNA fragmentation factor; Apoptosis; Amoebiasis; Alzheimer"s disease; Alpha6-Beta4 Integrin Signaling Pathway; Androgen Receptor Signaling Pathway; Apoptosis Modulation by HSP70; Apoptosis induced DNA fragmentation; Apoptotic cleavage of cellular proteins; Caspase cascade in apoptosis; Cell death signalling via NRAGE; Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; Herpes simplex infection; Huntington"s disease |