"CASP3" Related Products


Recombinant Human Caspase 3, Apoptosis-related Cysteine Peptidase

Cat. No. : CASP3-1642H
Product Overview : Recombinant full-length human CASP3 containing was expressed in E. coli.
Description : CASP3 (also know as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. CASP3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B.
Molecular Weight : large (17 kD) and small (11 kD) subunits
Source : E. coli
Species : Human
Form : Lyophilized powder.
Appearance : Lyophilized powder
Reconstitution : Reconstitute in PBS containing 15% glycerol.
Storage : The lyophilized caspase-3 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease.
Pathways : Activation of DNA fragmentation factor; Apoptosis; Amoebiasis; Alzheimer"s disease; Alpha6-Beta4 Integrin Signaling Pathway; Androgen Receptor Signaling Pathway; Apoptosis Modulation by HSP70; Apoptosis induced DNA fragmentation; Apoptotic cleavage of cellular proteins; Caspase cascade in apoptosis; Cell death signalling via NRAGE; Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; Herpes simplex infection; Huntington"s disease
Gene Name : CASP3 caspase 3, apoptosis-related cysteine peptidase [ Homo sapiens ]
Official Symbol : CASP3
Synonyms : CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; caspase-3; Yama; CASP-3; CPP-32; apopain; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine protease; Caspase-3; Apopain; Cysteine protease CPP32; Protein Yama; EC; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; OTTHUMP00000165055; OTTHUMP00000224230; OTTHUMP00000224231
Gene ID : 836
mRNA Refseq : NM_004346
Protein Refseq : NP_004337
MIM : 600636
UniProt ID : P42574
Chromosome Location : 4q34
Function : cysteine-type endopeptidase activity; peptidase activity; protein binding

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