Cat. No.:	CASP3-1642H
Product Overview:	Recombinant full-length human CASP3 containing was expressed in E. coli.
Description:	CASP3 (also know as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. CASP3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B.
Molecular Weight:	large (17 kD) and small (11 kD) subunits
Source:	E. coli
Species:	Human
Form:	Lyophilized powder.
Appearance:	Lyophilized powder
Reconstitution:	Reconstitute in PBS containing 15% glycerol.
Storage:	The lyophilized caspase-3 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease.
Pathways:	Activation of DNA fragmentation factor; Apoptosis; Amoebiasis; Alzheimer"s disease; Alpha6-Beta4 Integrin Signaling Pathway; Androgen Receptor Signaling Pathway; Apoptosis Modulation by HSP70; Apoptosis induced DNA fragmentation; Apoptotic cleavage of cellular proteins; Caspase cascade in apoptosis; Cell death signalling via NRAGE; Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; Herpes simplex infection; Huntington"s disease

Gene Name:	CASP3 caspase 3, apoptosis-related cysteine peptidase [ Homo sapiens ]
Official Symbol:	CASP3
Synonyms:	CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; caspase-3; Yama; CASP-3; CPP-32; apopain; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine protease; Caspase-3; Apopain; Cysteine protease CPP32; Protein Yama; EC 3.4.22.56; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; OTTHUMP00000165055; OTTHUMP00000224230; OTTHUMP00000224231
Gene ID:	836
mRNA Refseq:	NM_004346
Protein Refseq:	NP_004337
MIM:	600636
UniProt ID:	P42574
Chromosome Location:	4q34
Function:	cysteine-type endopeptidase activity; peptidase activity; protein binding

Online Inquiry