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Recombinant Human Caspase 3, Apoptosis-related Cysteine Peptidase
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Cat. No. : | CASP3-1642H |
Product Overview : | Recombinant full-length human CASP3 containing was expressed in E. coli. |
Description : | CASP3 (also know as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. CASP3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B. |
Molecular Weight : | large (17 kD) and small (11 kD) subunits |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized powder. |
Appearance : | Lyophilized powder |
Reconstitution : | Reconstitute in PBS containing 15% glycerol. |
Storage : | The lyophilized caspase-3 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease. |
Pathways : | Activation of DNA fragmentation factor; Apoptosis; Amoebiasis; Alzheimer"s disease; Alpha6-Beta4 Integrin Signaling Pathway; Androgen Receptor Signaling Pathway; Apoptosis Modulation by HSP70; Apoptosis induced DNA fragmentation; Apoptotic cleavage of cellular proteins; Caspase cascade in apoptosis; Cell death signalling via NRAGE; Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; Herpes simplex infection; Huntington"s disease |
Caspase31rhk. : |
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Gene Name : | CASP3 caspase 3, apoptosis-related cysteine peptidase [ Homo sapiens ] |
Official Symbol : | CASP3 |
Synonyms : | CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; caspase-3; Yama; CASP-3; CPP-32; apopain; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine protease; Caspase-3; Apopain; Cysteine protease CPP32; Protein Yama; EC 3.4.22.56; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; OTTHUMP00000165055; OTTHUMP00000224230; OTTHUMP00000224231 |
Gene ID : | 836 |
mRNA Refseq : | NM_004346 |
Protein Refseq : | NP_004337 |
MIM : | 600636 |
UniProt ID : | P42574 |
Chromosome Location : | 4q34 |
Function : | cysteine-type endopeptidase activity; peptidase activity; protein binding |
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◆ Lysates
CASP3-7838HCL | Recombinant Human CASP3 293 Cell Lysate | +Inquiry |
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