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Recombinant Human E1A Binding Protein P300, GST-tagged

Cat. No.: EP300-1584H
Product Overview: Recombinant human EP300 (532-1153; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein that functions as a histone acetyltransferase. EP300 regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. EP300 binding is a highly accurate process and can be used for identifying enhancers and their associated activities. EP300 is also useful in the study of the role of tissue-specific enhancers in human biology and diseases on a genome wide scale. Defects in EP300 gene are a cause of Rubinstein-Taybi syndrome that play a important role in epithelial cancer and act as a classic tumor suppressor gene.
Applications: Western Blot
Molecular Weight: 120 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Purity: > 80 %
Concentration: 0.1 ug/ul
Sequences: 532-1153; contains the catalytic domain
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: ATF-2 transcription factor network; Adherens junction; Androgen Receptor Signaling Pathway; C-MYB transcription factor network; Cell cycle; Delta-Notch Signaling Pathway; Diabetes pathways; Direct p53 effectors; E2F transcription factor network; Energy Metabolism; FOXA1 transcription factor network; FOXM1 transcription factor network; Influenza A; Melanogenesis; Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Gene Name: EP300 E1A binding protein p300 [ Homo sapiens ]
Official Symbol: EP300
Synonyms: EP300; E1A binding protein p300; p300; KAT3B; RSTS2; histone acetyltransferase p300; p300 HAT; E1A-binding protein, 300Kd; E1A-associated protein p300; OTTHUMP00000198754
Gene ID: 2033
mRNA Refseq: NM_001429
Protein Refseq: NP_001420
MIM: 602700
UniProt ID: Q09472
Chromosome Location: 22q13.2
Function: DNA binding; NF-kappaB binding; RNA polymerase II activating transcription factor binding; SMAD binding; acetyltransferase activity; activating transcription factor binding; acyltransferase activity; bHLH transcription factor binding; glucocorticoid receptor binding; histone acetyltransferase activity; metal ion binding; peroxisome proliferator activated receptor binding; transcription coactivator activity; contributes_to transcription coactivator activity; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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