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Recombinant Human Fms-Related Tyrosine Kinase 3, GST-tagged

Cat.No. : FLT3-1016H
Product Overview : Recombinant human FLT3 (571-993) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
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Cat. No. : FLT3-1016H
Description : FLT3 is a receptor tyrosine kinase that has been shown to play a role in proliferation and survival of hematopoietic progenitor cells as well as differentiation of early B lymphoid progenitors. FLT3 consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML).
Applications : Kinase Assay; Western Blot
Molecular Weight : 73 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Specific Activity : 70 nmol/min/mg
Purity : >75%
Concentration : 0.1 ug/ul
Sequences : 571-993
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Cytokine-cytokine receptor interaction; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer
Gene Name : FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ]
Official Symbol : FLT3
Synonyms : FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; FL cytokine receptor; FLT-3; STK-1; CD135 antigen; OTTHUMP00000018181; OTTHUMP00000214829; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; FLT3 receptor tyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factor receptor tyrosine kinase type III
Gene ID : 2322
mRNA Refseq : NM_004119
Protein Refseq : NP_004110
MIM : 136351
UniProt ID : P36888
Chromosome Location : 13q12
Function : ATP binding; nucleotide binding; phosphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is FLT3 implicated in acute myeloid leukemia (AML)? 12/24/2021

FLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.

In which cells or tissues is FLT3 predominantly expressed? 07/08/2021

FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.

How does FLT3 contribute to hematopoiesis? 03/15/2021

It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.

Are there therapeutic strategies targeting FLT3 for disease treatment? 08/01/2020

Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.

What is the primary biological function of FLT3 in cells? 06/27/2020

FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.

What role does FLT3 play in the proliferation and differentiation of hematopoietic stem cells? 07/14/2019

It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.

What are the common mutations found in FLT3 associated with diseases? 04/05/2019

Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.

Customer Reviews (3)

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Reviews
08/01/2021

    Excellent product, great price.

    12/22/2020

      Satisfied, will order again.

      09/14/2020

        Quick response, helpful service.

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