"FLT3" Related Products

Recombinant Human Fms-Related Tyrosine Kinase 3, GST-tagged

Cat. No. : FLT3-1016H
Product Overview : Recombinant human FLT3 (571-993) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Description : FLT3 is a receptor tyrosine kinase that has been shown to play a role in proliferation and survival of hematopoietic progenitor cells as well as differentiation of early B lymphoid progenitors. FLT3 consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML).
Applications : Kinase Assay; Western Blot
Molecular Weight : 73 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Specific Activity : 70 nmol/min/mg
Purity : >75%
Concentration : 0.1 ug/ul
Sequences : 571-993
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Cytokine-cytokine receptor interaction; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer
Gene Name : FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ]
Official Symbol : FLT3
Synonyms : FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; FL cytokine receptor; FLT-3; STK-1; CD135 antigen; OTTHUMP00000018181; OTTHUMP00000214829; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; FLT3 receptor tyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factor receptor tyrosine kinase type III
Gene ID : 2322
mRNA Refseq : NM_004119
Protein Refseq : NP_004110
MIM : 136351
UniProt ID : P36888
Chromosome Location : 13q12
Function : ATP binding; nucleotide binding; phosphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

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