Recombinant Mouse Flt3 Protein (Gly27-Arg188), C-Fc tagged

• Cat.No.: Flt3-5668M
• Product Overview: Recombinant mouse Flt3 (Gly27-Arg188) fused with the C-terminal Fc tag was expressed in mammalian cells.

Specification

• Source: Mammalian cells
• Species: Mouse
• Tag: Fc
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 42.82 kDa
• Protein length: Gly27-Arg188
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS or lyophilized from PBS.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: Flt3 FMS-like tyrosine kinase 3 [ Mus musculus (house mouse) ]
• Official Symbol: Flt3
• Synonyms: FLT3; FMS-like tyrosine kinase 3; receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; fetal liver kinase 2; tyrosine-protein kinase FLT3; tyrosine-protein kinase receptor flk-2; Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04; MGC124377; MGC124378
• Gene ID: 14255
• mRNA Refseq: NM_010229
• Protein Refseq: NP_034359
• UniProt ID: Q00342

Reviews

08/01/2021

Excellent product, great price.

12/22/2020

Satisfied, will order again.

09/14/2020

Quick response, helpful service.

Q&As

How is FLT3 implicated in acute myeloid leukemia (AML)?

FLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.

In which cells or tissues is FLT3 predominantly expressed?

FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.

How does FLT3 contribute to hematopoiesis?

It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.

Are there therapeutic strategies targeting FLT3 for disease treatment?

Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.

What is the primary biological function of FLT3 in cells?

FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.

What role does FLT3 play in the proliferation and differentiation of hematopoietic stem cells?

It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.

What are the common mutations found in FLT3 associated with diseases?

Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.