FLT3
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Official Full Name
fms-related tyrosine kinase 3
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Overview
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008] -
Synonyms
FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; FLK-2; receptor-type tyrosine-protein kinase FLT3; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III;
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- His
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- GST
- hIgG4
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- T7
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- DDK
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- Non
- Involved Pathway
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- Interacting Protein
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FLT3 involved in several pathways and played different roles in them. We selected most pathways FLT3 participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IFNA21;BMPR1BB;IL25;IL2RG;EDA;IL24;IFNA5;CCL4L1;ACKR3B |
| Hematopoietic cell lineage | Itga10&Itgb1;CD1A;IL11RA2;CD34;CR1;Il6ra;Cd24a;GP1BB;CD4 |
| Pathways in cancer | FGF5;RAC1;ARHGEF12;GNB1;CBL;SFPI1;ROCK2;CCND1;ITGA6 |
| Transcriptional misregulation in cancer | PER2;PTK2;ETV5;HIST2H3A;MDM2;FLT3;H3F3C;DDX5;GRIA3 |
| Acute myeloid leukemia | AKT3;PIM1;PIK3R2;TCF7;FLT3;ZBTB16;CCNA1;KIT;PIK3R3 |
| Central carbon metabolism in cancer | HK3;MTOR;PIK3R1;PKM;PIK3CD;PFKP;NRAS;GLS;PFKM |
FLT3 has several biochemical functions, for example, ATP binding, cytokine receptor activity, phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT3 itself. We selected most functions FLT3 had, and list some proteins which have the same functions with FLT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | EPHB4B;KLHL8;EIF4A1;MAPK8;KIF4A;PGK1;KATNAL1;VPRBP;MOV10B.2 |
| cytokine receptor activity | IL12RB1;IL2RGA;FLT3;IL11RA;CSF3R;IL13RA2;IRX1;F3B;GHR |
| phosphatidylinositol 3-kinase binding | BECN1;IGF1RB;CALM2;HCST;INSRB;CALM3;DAB1;IRS1;PDGFRB |
| protein binding | EIF4E;TBX5;MDFIC;PPP4R1;CYFIP2;MPHOSPH8;C19orf47;TTC19;ASF1B |
| protein homodimerization activity | ZBTB1;CHUK;ERN1;C1QB;PVRL2L;UGT1A6;UGT1A2;IRAK2;PVRL2 |
| transmembrane receptor protein tyrosine kinase activity | NTRK3;CSF1RA;MERTK;INSRA;KITA;IGF1RB;NTRK1;ERBB3A;ROR2 |
| vascular endothelial growth factor-activated receptor activity | KDR;FLT3;NRP2;PDGFRA;NRP1B;NRP1;NRP2A;FLT4;FLT1 |
FLT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT3.
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Q&As (7)
Ask a questionFLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.
FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.
It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.
Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.
FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.
It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.
Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.
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