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FLT3

  • Official Full Name

    fms-related tyrosine kinase 3

  • Overview

    This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
  • Synonyms

    FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; FLK-2; receptor-type tyrosine-protein kinase FLT3; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Porcine
  • Rhesus monkey
  • Rhesus Monkey
  • E.coli
  • E.coli-derived, PGEX-4T
  • HEK293
  • HEK293T
  • Hordeum Vulgare
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Nicotiana Benthamiana
  • S.frugiperda
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • Fc
  • hFc
  • 6×His
  • His
  • Myc
  • DDK
  • DDK|His
  • Fc Chimera
  • Flag
  • GST
  • GST|His
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|T7
  • human|IgG1|Fc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FLT3-185H Active Recombinant Human FLT3 protein Insect Cell N/A 155 amino acids
Human FLT3-140H Active Recombinant Human Fms-related Tyrosine Kinase 3, Fc Chimera HEK293 Fc
Human FLT3-259H Active Recombinant Human FLT3 (D835Y), GST-tagged Sf9 Insect Cell GST
Human FLT3-155H Active Recombinant Human FLT3, Fc Chimera Mammalian cells Fc Chimera
Human FLT3-4902H Active Recombinant Human FLT3 protein, GST/His-tagged Insect Cell GST/His
Human Flt3-2170H Active Recombinant Human Flt3 protein, His-tagged HEK293 His Asn 27 - Ser 543
Human FLT3-04H Recombinant Human FLT3 E.coli-derived, PGEX-4T N/A
Human FLT3-1016H Recombinant Human Fms-Related Tyrosine Kinase 3, GST-tagged Sf9 Insect Cell GST
Human FLT3-157H Recombinant Human FLT3 protein, DDK/His-tagged HEK293 DDK/His Asn27 – Ser543
Human FLT3-28340TH Recombinant Human FLT3, His-tagged His
Human FLT3-208H Recombinant Human FLT3 Mammalian Cell His
Human FLT3-545H Recombinant Human Fms-Related Tyrosine Kinase 3, His-tagged Sf9 Insect Cell His
Human FLT3-1550H Recombinant human FLT3, Active Nicotiana Benthamiana N/A
Human FLT3-494H Recombinant Human Fms-related Tyrosine Kinase 3 Mammalian cells N/A
Human FLT3-158H Recombinant Human FLT3 protein, DDK-tagged Insect Cell DDK Met-Asn27-Ser543
Human FLT3-28417TH Recombinant Human FLT3 protein, Fc-tagged HEK293 human/IgG1/Fc Asn27-Ser543
Human FLT3-2243H Active Recombinant Human FLT3, His tagged HEK293 His Met1-Asn541
Human VCL-230H Recombinant Human VCL protein E.coli N/A
Human FLT3-48H Recombinant Human FLT3 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human FLT3-688H Recombinant Human FLT3, GST-His S.frugiperda GST
Human FLT3-1226H Recombinant Human Fms-Related Tyrosine Kinase 3 Hordeum Vulgare N/A
Human FLT3-28413TH Recombinant Human FLT3 E.coli N/A
Human FLT3-763H Recombinant Human FLT3 protein, His & T7-tagged E.coli His/T7 Lys334~Ser543 (Accession # P36888)
Human FLT3-12937H Recombinant Human FLT3, GST-tagged E.coli GST 27-376a.a.
Human FLT3-28342TH Recombinant Human FLT3 N/A
Human FLT3-319H Recombinant Human FLT3, GST-tagged, Active Sf9 Insect Cell GST
Human FLT3-1225H Recombinant Human Fms-Related Tyrosine Kinase 3 HEK293 N/A
Human FLT3-2561HCL Recombinant Human FLT3 cell lysate Human Cell N/A
Human FLT3-1454H Active Recombinant Human FLT3 protein, Fc-tagged, FITC-Labeled HEK293 Fc Asn27-Ser543
Human FLT3-038H Recombinant Human FLT3 Protein, C-His-tagged E.coli C-His
Human FLT3-4136H Recombinant Human FLT3 Protein (Met1-Asn541), C-His tagged Mammalian cells C-His Met1-Asn541
Human FLT3-2243HAF488 Recombinant Human FLT3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 526
Human FLT3-1455H Active Recombinant Human FLT3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Asn27-Ser543
Human Flt3-1430H Active Recombinant Human Flt3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Thr27-Pro185
Human FLT3-2243HAF555 Recombinant Human FLT3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 526
Human FLT3-2243HF Recombinant Human FLT3 Protein, His-tagged, FITC conjugated HEK293 His 526
Human FLT3-1134H Recombinant Human FLT3 Protein (Asn27-Tyr376), N-His tagged E.coli N-His Asn27-Tyr376
Human Flt3-1432H Active Recombinant Human Flt3 protein HEK293 N/A Thr27-Pro185
Human FLT3-4371H Recombinant Human FLT3 Protein, GST-tagged Wheat Germ GST
Human FLT3-4370H Active Recombinant Human FLT3 Protein, GST-tagged Insect Cell GST
Human FLT3-3241H Recombinant Human FLT3 Protein (His564-Ser993), N-His tagged E.coli N-His His564-Ser993
Human FLT3-167H Recombinant Human FLT3 Protein (Asn27-Ser543), C-hFc and 6×His-tagged HEK293 C-hFc and 6×His Asn27-Ser543
Human FLT3-05H Active Recombinant Human FLT3 protein, Fc-tagged HEK293 Fc Asn 27 - Ser 543
Human FLT3-2340H Recombinant Human FLT3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FLT3-088H Recombinant Human FLT3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human FLT3-984HFL Recombinant Full Length Human FLT3 Protein, C-Flag-tagged Mammalian cells Flag
Human FLT3-107H Recombinant Human FLT3 protein, His-Avi-tagged HEK293 His-Avi It contains Asn 27 - Asn 541.
Human FLT3-29HG Recombinant Human FLT3 Protein, GMP Grade, Animal-Free E.coli
Human FLT3-151H Recombinant Human FLT3 Protein, His-tagged Human Cells His
Human FLT3-188H-B Recombinant Human FLT3 Protein Pre-coupled Magnetic Beads HEK293
Human FLT3-2243HAF647 Recombinant Human FLT3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 526
Human FLT3-188H Recombinant Human FLT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FLT3-303M Recombinant Mouse FLT3 protein, His-tagged HEK293 His Met1-Ser544
Mouse Flt3-500M Recombinant Mouse FMS-like Tyrosine Kinase 3 Mammalian cells N/A
Mouse Flt3-764M Recombinant Mouse Flt3 protein, His & T7-tagged E.coli His/T7 Lys335~Ser544 (Accession # Q00342)
Mouse FLT3-970MCL Recombinant Mouse FLT3 cell lysate Human Cell N/A
Mouse Flt3-1431M Active Recombinant Mouse Flt3 protein, His-tagged HEK293 His Gly27-Arg188
Mouse FLT3-1456M Recombinant Mouse FLT3 protein, His-tagged HEK293 His Asn28-Ser544
Mouse Flt3-5669M Recombinant Mouse Flt3 Protein (Gly27-Arg188), C-His tagged Mammalian cells C-His Gly27-Arg188
Mouse Flt3-3045M Recombinant Mouse Flt3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Flt3-5668M Recombinant Mouse Flt3 Protein (Gly27-Arg188), C-Fc tagged Mammalian cells C-Fc Gly27-Arg188
Mouse Flt3-10555M-B Recombinant Mouse Flt3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Flt3-10555M Recombinant Mouse Flt3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FLT3-1234M Active Recombinant Mouse FLT3 protein, hFc-tagged HEK293 hFc Asn28-Ser544
Rhesus monkey FLT3-1567R Recombinant Rhesus Monkey FLT3 Protein HEK293 N/A
Rhesus monkey FLT3-1568R Recombinant Rhesus Monkey FLT3 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey FLT3-1569R Recombinant Rhesus Monkey FLT3 Protein, hIgG4-tagged HEK293 hIgG4
Rhesus Monkey FLT3-1155R Recombinant Rhesus Monkey FLT3 Protein, His-tagged HEK293 His aa.32-542
Porcine FLT3-97P Active Recombinant Porcine FLT-3 Ligand Protein E.coli
Porcine FLT3-98P Active Recombinant Porcine FLT-3 Ligand Protein E.coli
Kit-1593 Flt3 Activity Assay Kit N/A
Kit-1592 Flt3 ActivityAssay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

FLT3 involved in several pathways and played different roles in them. We selected most pathways FLT3 participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNFSF18;TNFRSF11A;PDGFC;IFNA17;CCL28;IFNA7;CCR1L1;TNFSF11;LEPB
Hematopoietic cell lineageCR2;IL4R;CD8B;CD3E; CD3D;GP5;ITGA2B;MS4A1;IL1B;Il6ra
Pathways in cancerBRCA2;PTK2;BCR;TRAF5;MMP9;MSH2;RASSF1;MET;PLCG1
Transcriptional misregulation in cancerASPSCR1;WHSC1;MAF;RUNX1;HHEX;HIST1H3E;RARA;GRIA3;RUNX1T1
Acute myeloid leukemiaSOS1;IKBKG;EIF4EBP1;HRAS;RUNX1;PML;PIK3CB;RELA;AKT2
Central carbon metabolism in cancerMAP2K2;MAPK1;C12orf5;MTOR;HIF1A;PDHA2;PIK3R5;FLT3;PFKL

FLT3 has several biochemical functions, for example, ATP binding, cytokine receptor activity, phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT3 itself. We selected most functions FLT3 had, and list some proteins which have the same functions with FLT3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingRTCD1;MYO7A;TRIB3;KIF13B;NOD1;MET;FES;MOS;ABCB5
cytokine receptor activityIL20RA;Il6ra;IL1RL1;LIFRB;IL13RA1;IL4R.1;F3A;FLT3;CRFB2
phosphatidylinositol 3-kinase bindingIRS2;DAB1;CALM2;TYRO3;INSRR;HCST;LCK;IGF1RB;INSRA
protein bindingCIB4;GTF2F1;SNRNP25;SPG20;NAA38;SIRT1;HAND2;CD81;IL10RB
protein homodimerization activityUSH1G;ERN1;DGCR8;S100A10;HLA-G;PVRL4;BHLHB9;TIMM9;RIPK2
transmembrane receptor protein tyrosine kinase activityEPHA4A;MERTK;EPHA2A;FGFR1B;INSRA;TIE1;CADM2B;ROR2;RYK
vascular endothelial growth factor-activated receptor activityNRP1A;NRP1B;KDR;NRP2B;FLT3;FLT4;NRP2A;NRP1;PDGFRA

FLT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT3.

SYK

Research Area

Related articles

Kato, T; Sakata-Yanagimoto, M; et al. Hes1 suppresses acute myeloid leukemia development through FLT3 repression. LEUKEMIA 29:576-585(2015).
Nocturne, G; Mariette, X; et al. Sjogren Syndrome-associated lymphomas: an update on pathogenesis and management. BRITISH JOURNAL OF HAEMATOLOGY 168:317-327(2015).
  • Q&As
  • Reviews

Q&As (7)

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How is FLT3 implicated in acute myeloid leukemia (AML)? 12/24/2021

FLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.

In which cells or tissues is FLT3 predominantly expressed? 07/08/2021

FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.

How does FLT3 contribute to hematopoiesis? 03/15/2021

It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.

Are there therapeutic strategies targeting FLT3 for disease treatment? 08/01/2020

Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.

What is the primary biological function of FLT3 in cells? 06/27/2020

FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.

What role does FLT3 play in the proliferation and differentiation of hematopoietic stem cells? 07/14/2019

It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.

What are the common mutations found in FLT3 associated with diseases? 04/05/2019

Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.

Customer Reviews (3)

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Reviews
08/01/2021

    Excellent product, great price.

    12/22/2020

      Satisfied, will order again.

      09/14/2020

        Quick response, helpful service.

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