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Recombinant Human ACE

Cat.No.: ACE-8304H
Product Overview: A DNA sequence encoding Human ACE was expressed.
Description: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.
Species: Human
Form: This recombinant protein was 0.2 μm filtered and is supplied in a solution of sodium chloride (NaCl), zinc chloride (ZnCl2), tris and glycerol.
Molecular Mass: The predicted molecular weight of Recombinant Human CD143 is Mr 143 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 160-180 kDa.
AA Sequence: l dpglqpgnfs adeagaqlfa qsynssaeqv lfqsvaaswa hdtnitaena rrqeeaalls qefaeawgqk akelyepiwq nftdpqlrri igavrtlgsa nlplakrqqy nallsnmsri ystakvclpn ktatcwsldp dltnilassr syamllfawe gwhnaagipl kplyedftal sneaykqdgf tdtgaywrsw ynsptfeddl ehlyqqlepl ylnlhafvrr alhrrygdry inlrgpipah llgdmwaqsw eniydmvvpf pdkpnldvts tmlqqgwnat hmfrvaeeff tslelspmpp efwegsmlek padgrevvch asawdfynrk dfrikqctrv tmdqlstvhh emghiqyylq ykdlpvslrr ganpgfheai gdvlalsvst pehlhkigll drvtndtesd inyllkmale kiaflpfgyl vdqwrwgvfs grtppsrynf dwwylrtkyq gicppvtrne thfdagakfh vpnvtpyiry fvsfvlqfqf healckeagy egplhqcdiy rstkagaklr kvlqagssrp wqevlkdmvg ldaldaqpll kyfqpvtqwl qeqnqqngev lgwpeyqwhp plpdnypegi dlvtdeaeas kfveeydrts qvvwneyaea nwnyntnitt etskillqkn mqianhtlky gtqarkfdvn qlqnttikri ikkvqdlera alpaqeleey nkilldmett ysvatvchpn gsclqlepdl tnvmatsrky edllwawegw rdkagrailq fypkyvelin qaarlngyvd agdswrsmye tpsleqdler lfqelqplyl nlhayvrral hrhygaqhin legpipahll gnmwaqtwsn iydlvvpfps apsmdtteam lkqgwtprrm fkeaddffts lgllpvppef wnksmlekpt dgrevvchas awdfyngkdf rikqcttvnl edlvvahhem ghiqyfmqyk dlpvalrega npgfheaigd vlalsvstpk hlhslnllss eggsdehdin flmkmaldki afipfsylvd qwrwrvfdgs itkenynqew wslrlkyqgl cppvprtqgd fdpgakfhip ssvpyiryfv sfiiqfqfhe alcqaaghtg plhkcdiyqs keagqrlata mklgfsrpwp eamqlitgqp nmsasamlsy fkplldwlrt enelhgeklg wpqynwtpns arsegplpds grvsflgldl daqqarvgqw lhhhhhhhhh h
Endotoxin: <1.0 eu/μg as determined by the lal>
Purity: >95% by SDS-PAGE and analyzed by silver stain.
Storage: Working aliquots of this recombinant protein solution are stable for up to six months at -20°C to -70°C in a manual defrost freezer. Upon thawing, in the presence of a carrier protein, this recombinant protein can be stored at -20° to -70°C for three months without detectable loss of activity. For long-term storage, aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
Gene Name: ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [ Homo sapiens ]
Official Symbol: ACE
Synonyms: ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; DCP1; angiotensin-converting enzyme; ACE1; CD143; kininase II; peptidase P; CD143 antigen; testicular ECA; carboxycathepsin; dipeptidyl carboxypeptidase 1; dipeptidyl carboxypeptidase I; angiotensin converting enzyme, somatic isoform; DCP; ICH; MVCD3;
Gene ID: 1636
mRNA Refseq: NM_000789
Protein Refseq: NP_000780
UniProt ID: P12821
Chromosome Location: 17q23.3
Pathway: ACE Inhibitor Pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem; Renin-angiotensin system, organism-specific biosystem; Renin-angiotensin system, conserved biosystem;
Function: actin binding; bradykinin receptor binding; carboxypeptidase activity; chloride ion binding; drug binding; endopeptidase activity; metal ion binding; metallopeptidase activity; metallopeptidase activity; peptidase activity; peptide binding; peptidyl-dipeptidase activity; peptidyl-dipeptidase activity; protein binding; zinc ion binding;

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