Recombinant Human BMP2
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Cat.No. : | BMP2-23H |
Product Overview : | Recombinant, human bone morphogenetic protein-2(BMP-2) expressed in CHO cell and purified byproprietary chromatographic methods. |
Description : | BMP-2 is a homodimeric protein that belongs to the transforming growth factor β (TGF-β) superfamily. BMP-2 is known to regulate diverse fundamental processes during embryonic development. BMP-2 have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. |
Source : | CHO Cells |
Species : | Human |
Form : | Lyophilized from a 0.2 μm filtered solution in 0.2% sucrose, 2.5% Glycine, 0.01% polysorbate 80, 0.01%sodium chloride, 3% mannitol per 1 μg of BMP-2. |
Bio-activity : | The ED50 as determined by cytolysis of ATDC-5 cell is less than 50 ng/ml. |
Molecular Mass : | The molecule has a calculated molecular mass of approximately 26 kDa. Due to glycosylation, rhBMP-2migrates as an approximately 36 kDa protein under non-reducing conditions and as a 17 - 18 kDa proteinunder reducing conditions in SDS-PAGE. |
Endotoxin : | <0.5 eu per 1 μg of bmp-2 as determined by the lal</0.5 |
Purity : | >95% as determined by SEC-HPLC and SDS-PAGE. |
Storage : | Lyophilized samples are stable for up to six months at -20° C to -70° C. |
Reconstitution : | Reconstitute to 100 μg/mL with sterile distilled water. Further dilutions can be made in aqueous buffersjust prior to use. |
Gene Name : | BMP2 bone morphogenetic protein 2 [ Homo sapiens ] |
Official Symbol : | BMP2 |
Synonyms : | BMP2; bone morphogenetic protein 2; BMP2A; BMP-2A; bone morphogenetic protein 2A; BDA2; |
Gene ID : | 650 |
mRNA Refseq : | NM_001200 |
Protein Refseq : | NP_001191 |
MIM : | 112261 |
UniProt ID : | P12643 |
Chromosome Location : | 20p12 |
Pathway : | Adipogenesis, organism-specific biosystem; BMP Signalling Pathway, organism-specific biosystem; Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Heart Development, organism-specific biosystem; |
Function : | BMP receptor binding; SMAD binding; activin receptor activity, type II; cytokine activity; growth factor activity; phosphatase activator activity; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; receptor binding; retinol dehydrogenase activity; transmembrane receptor protein serine/threonine kinase activity; |
◆ Recombinant Protein
BMP2-561H | Recombinant Human BMP2 protein, His-tagged | +Inquiry |
Bmp2-211M | Recombinant Mouse Bmp2 protein, His/S-tagged | +Inquiry |
BMP2-259H | Recombinant Human BMP2 protein, His-tagged | +Inquiry |
BMP2-567C | Recombinant Cattle BMP2 protein, His-tagged | +Inquiry |
Bmp2-212R | Recombinant Rat Bmp2 protein, His/S-tagged | +Inquiry |
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◆ Lysates
BMP2-3075HCL | Recombinant Human BMP2 cell lysate | +Inquiry |
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