Recombinant Human PCSK9, HIS/HA/AVI-tagged

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Recombinant Human PCSK9, HIS/HA/AVI-tagged

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Cat.No. : PCSK9-153H
Product Overview : Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (biotinylated with His tag) is produced by our mammalian expression system. The target protein is expressed with sequence (Q31-Q692) of Human PCSK9 fused with a HIS/HA/AVI tag at the C-terminus.
Description : Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
Source : HEK293
Species : Human
Tag : HIS/HA/AVI
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Gene Name : PCSK9 proprotein convertase subtilisin/kexin type 9 [ Homo sapiens ]
Official Symbol : PCSK9
Synonyms : PCSK9; proprotein convertase subtilisin/kexin type 9; HCHOLA3, hypercholesterolemia, autosomal dominant 3; FH3; NARC 1; NARC1; NARC-1; HCHOLA3;
Gene ID : 353175
MIM : 607786
UniProt ID : Q8NBP7
Chromosome Location : 1p34.1-p32
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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