Recombinant Rhesus Macaque PCSK9 Protein, His (Fc)-Avi-tagged
|Product Overview :||Recombinant Rhesus Macaque PCSK9 with His (Fc)-Avi tag was expressed and purified|
- Gene Information
- Related Products
|Species :||Rhesus Macaque|
|Tag :||His (Fc)-Avi|
|Endotoxin :||< 1.0 EU per μg of the protein as determined by the LAL method|
|Purity :||≥85% by SDS-PAGE|
|Stability :||Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.|
|Storage :||For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.|
|Storage Buffer :||PBS buffer|
|Gene Name :||PCSK9 proprotein convertase subtilisin/kexin type 9 [ Macaca mulatta (Rhesus monkey) ]|
|Official Symbol :||PCSK9|
|Synonyms :||PCSK9; PC9; proprotein convertase subtilisin/kexin type 9; proprotein convertase 9; proprotein convertase PC9; proprotein convertase subtilisin/kexin type 9 preproprotein; subtilisin/kexin-like protease PC9;|
|Gene ID :||717147|
|mRNA Refseq :||NM_001112660|
|Protein Refseq :||NP_001106130|
|UniProt ID :||A8T666|
|◆ Recombinant Protein|
|Pcsk9-6566M||Recombinant Mouse Pcsk9 Protein, His (Fc)-Avi-tagged||+Inquiry|
|PCSK9-352H||Active Recombinant Human PCSK9 Protein, His & Avi-tagged, Biotinylated||+Inquiry|
|Pcsk9-412M||Recombinant Mouse Pcsk9 Protein, His-tagged||+Inquiry|
|PCSK9-406C||Recombinant Chinese hamster PCSK9 Protein, His-tagged||+Inquiry|
|PCSK9-414R||Recombinant Rhesus macaque PCSK9 Protein, His-tagged||+Inquiry|
|PCSK9-2564MCL||Recombinant Mouse PCSK9 cell lysate||+Inquiry|
|PCSK9-2875HCL||Recombinant Human PCSK9 cell lysate||+Inquiry|
|PCSK9-2306RCL||Recombinant Rat PCSK9 cell lysate||+Inquiry|
|◆ Assay kits|
|Kit-1806||PCSK9(D374T)-LDLR TR-FRET Assay Kit||+Inquiry|
|Kit-1808||PCSK9-LDLR TR-FRET Assay Kit||+Inquiry|
|Kit-1807||PCSK9[Biotinylated]-LDLR Binding Assay Kit||+Inquiry|
|Kit-0665||PCSK9-BIRC2 in vitro Binding Assay Kit||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
Yes, some studies suggest that mutations in the PCSK9 protein gene may increase the risk of cardiovascular disease. For example, some PCSK9 mutations can cause their dysfunction, resulting in hypercholesterolemia and cardiovascular disease.
PCSK9 protein is combined with immune adjuvants to make a vaccine, or mutated PCSK9 protein to induce an immune response to it, inhibit PCSK9 expression in vivo, increase LDLR levels and reduce serum cholesterol levels.
This protein may have a regulatory effect on weight and obesity, and it is associated with glucose and endocannabinin homeostasis studies have linked PCSK9 to the development of obesity and diabetes.
Several new anti-PCSK9 drugs are already being studied and developed, including oral drugs and gene chromosome therapies, and some drugs have advanced to early stages of clinical trials, providing new options for the treatment of PCSK9 proteins.
Currently on the market to inhibit PCSK9 protein drugs include alirocumab and evolocumab.
PCSK9 protein can degrade LDLR protein, so its overexpression will lead to a decrease in LDLR's ability to be cleared, leading to hypercholesterolemia.
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