Recombinant human TGFB2, Active
Cat.No. : | TGFB2-1566H |
Product Overview : | Recombinant human TGF-β2 is a 27.08 kDa protein composed of two identical 118 amino acid polypeptide chains linked by a single disulphide bond. |
- Specification
- Gene Information
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Description : | Recombinant human TGF-β2 is a 27.08 kDa protein composed of two identical 118 amino acid peptide chains linked by a single disulphide bond. Transforming growth factor–β is a family of five related cytokines that have been shown on a wide variety of normal and neoplastic cells, indicating the importance of these homo-dimmer proteins as multi-functional regulators of cellular activity. The three mammalian isoforms of TGF-β (TGF-β1, TGF-β2 and TGF-β3) signal through the same receptor and elicit similar biological responses. They are involved in physiological processes as embryogenesis, tissue remodelling and wound healing. |
Source : | Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal–derived components or impurities. Animal Free product. |
Species : | Human |
Form : | Recombinant human TGF-b2 is lyophilized from a Tris HCl 0.05M buffer at pH 7.4. |
Molecular Mass : | 27.08 kDa |
AA Sequence : | HHHHHHALDAAYCFRNVQDNCCLRP LYIDFKRDLGWKWIHEPKGYNANFC AGACPYLWSSDTQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGK TPKIEQLSNMIVKSCKCS |
Endotoxin : | < 0.04 eu/μg protein (lal> |
Purity : | >97% by SDS-PAGE gel |
Storage : | This lyophilized preparation is stable at 2-8o C for short term, long storage it should be kept at -20oC. Reconstituted protein should be stored in working aliquots at –20°C. Repeated freezing and thawing is not recommended. |
Reconstitution : | Centrifuge vial before opening. Lyophilized protein should be reconstituted in water to a concentration of 25ng/ul. At higher concentration the solubility may be reduced and multimers generated. |
Gene Name : | TGFB2 transforming growth factor, beta 2 [ Homo sapiens ] |
Official Symbol : | TGFB2 |
Synonyms : | TGFB2; transforming growth factor, beta 2; transforming growth factor beta-2; G-TSF; cetermin; polyergin; BSC-1 cell growth inhibitor; glioblastoma-derived T-cell suppressor factor; TGF-beta2; MGC116892; |
Gene ID : | 7042 |
mRNA Refseq : | NM_001135599 |
Protein Refseq : | NP_001129071 |
MIM : | 190220 |
UniProt ID : | P61812 |
Chromosome Location : | 1q41 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; |
Function : | beta-amyloid binding; cytokine activity; growth factor activity; protein binding; contributes_to protein binding; protein heterodimerization activity; protein homodimerization activity; receptor binding; receptor signaling protein serine/threonine kinase |
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◆ Lysates | ||
TGFB2-1119HCL | Recombinant Human TGFB2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIt can promote wound healing and tissue repair by stimulating the proliferation and migration of fibroblasts and epithelial cells, as well as promoting collagen synthesis.
Inhibitors or activators targeting TGFB2 may have potential applications for the treatment of a variety of diseases, including cancer, inflammatory diseases, autoimmune diseases, etc.
TGFB2 can regulate cell proliferation and differentiation by binding to its receptor and activating downstream signal transduction pathways.
This protein can be used as an immunomodulator to participate in the differentiation and function of immune cells, as well as the regulation of inflammatory responses.
The expression level of TGFB2 is regulated by a variety of factors, including transcription factors, signal transduction pathways, and epigenetic modifications.
TGFB2 has a variety of associations with other proteins and cytokines. For example, it may interact with vascular endothelial growth factor (VEGF) and be involved in angiogenesis, and may also interact with apoptosis-related proteins to regulate the apoptotic process.
Customer Reviews (3)
Write a reviewNo complicated experimental steps, suitable for beginners.
Excellent performance in Western blot, even if stored for a long time will not affect its performance.
The endotoxin levels were low enough not to interfere with the results.
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