Recombinant Human Pro-matrix metallopeptidase 9, His-tagged

• Cat.No.: Pro-MMP9-109H
• Product Overview: Recombinant Human Pro-MMP-9 comprises a 688aa fragment (20-707) corresponding to the pro form of the protein minus the signal peptide and is expressed in E. coli with an N-terminal 6xHis tag.

Specification

• Cat. No.: Pro-MMP9-109H
• Description: Matrix metalloproteinases are a family of zinc- and calcium-dependant endopeptidases, which degrade extracellular matrix proteins. MMP-9 is secreted as a 92kDa zymogen. Cleavage of pro-MMP-9 results in the active enzyme with a molecular weight of ~82kDa. MMP-9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodelling, wound healing, tumour growth and metastasis.
• Source: E.coli.
• Purity: >95% by SDS-PAGE
• Form: Liquid
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
• Synonyms: Matrix metalloproteinase 9; gelatinase B; 92kD gelatinase; 92kD type IV collagenase precursor;CLG4B; GELB; MMP9; CLG4B; GELB; MMP-9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9; OTTHUMP00000031674; type V collagenase; macrophage gelatinase; EC 3.4.24.35; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase).

Gene Information

• Synonyms: Matrix metalloproteinase 9; gelatinase B; 92kD gelatinase; 92kD type IV collagenase precursor;CLG4B; GELB; MMP9; CLG4B; GELB; MMP-9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9; OTTHUMP00000031674; type V collagenase; macrophage gelatinase; EC 3.4.24.35; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase).