"AXIN1" Related Products


Recombinant Human AXIN1, MYC/DDK-tagged

Cat.No.: AXIN1-106H
Product Overview: Recombinant Human AXIN1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
Source: HEK293 cells
Species: Human
Molecular Mass: 91.5 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: AXIN1 axin 1 [ Homo sapiens (human) ]
Official Symbol: AXIN1
Synonyms: AXIN1; axin 1; axin-1; PPP1R49; protein phosphatase 1; regulatory subunit 49; axis inhibitor 1; fused, mouse, homolog of; axis inhibition protein 1; protein phosphatase 1, regulatory subunit 49; AXIN; MGC52315
Gene ID: 8312
mRNA Refseq: NM_181050
Protein Refseq: NP_851393
MIM: 603816
UniProt ID: O15169
Chromosome Location: 16p13.3
Pathway: AMER1 mutants destabilize the destruction complex; APC truncation mutants have impaired AXIN binding; Basal cell carcinoma
Function: GTPase activator activity; R-SMAD binding; armadillo repeat domain binding

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