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AXIN1

  • Official Full Name

    axin 1

  • Overview

    Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
  • Synonyms

    AXIN1; axin 1; axin-1; PPP1R49; protein phosphatase 1; regulatory subunit 49; AI316800; AXIN; Axin 1; Axin-1; axin1; AXIN1_HUMAN; Axis inhibition protein 1; Axis Inhibitor 1; hAxin; Kb; Ki; kinky; knobbly; axis inhibition protein 1; protein phosphatase 1, regulatory subunit 49; AXIN;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AXIN1-105H Recombinant Human AXIN1, GST-tagged Wheat Germ GST
Human AXIN1-10084H Recombinant Human AXIN1, His-tagged E.coli His 1-351a.a.
Human AXIN1-665H Recombinant Human AXIN1 Mammalian Cell His
Human AXIN1-106H Recombinant Human AXIN1, MYC/DDK-tagged HEK293 Myc/DDK
Human AXIN1-26564TH Recombinant Human AXIN1, His-tagged E.coli His
Human AXIN1-1047H Recombinant Human AXIN1 protein, GST-tagged Wheat Germ GST
Human AXIN1-1983H Recombinant Human AXIN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AXIN1-4718HFL Recombinant Full Length Human AXIN1, Flag-tagged Mamanlian cells Flag
Human AXIN1-1818H Recombinant Human AXIN1 protein, GST-tagged E.coli GST 1-351 aa
Human AXIN1-388H Recombinant Human AXIN1 Protein, His-tagged E.coli His Ser653~Asp862
Human AXIN1-2524H Recombinant Human AXIN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AXIN1-01H Recombinant Human AXIN1 Protein Sf9 Insect Cell
Human AXIN1-2524H-B Recombinant Human AXIN1 Protein Pre-coupled Magnetic Beads HEK293
Human AXIN1-02H Recombinant Human AXIN1 Protein, GST-Tagged Sf9 Insect Cell GST
Mouse Axin1-3793M Recombinant Mouse Axin1, His-tagged E.Coli or Yeast His 868
Mouse Axin1-389M Recombinant Mouse Axin1 Protein, His-tagged E.coli His Lys654~Asp863
Mouse Axin1-684M Recombinant Mouse Axin1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat AXIN1-909R Recombinant Rat AXIN1 Protein Mammalian Cell His
Rat Axin1-390R Recombinant Rat Axin1 Protein, His-tagged E.coli His Thr618~Asp827
Rat AXIN1-565R Recombinant Rat AXIN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AXIN1-565R-B Recombinant Rat AXIN1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish AXIN1-9053Z Recombinant Zebrafish AXIN1 Mammalian Cell His
Chicken AXIN1-6504C Recombinant Chicken AXIN1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AXIN1 Related Articles
  • AXIN1 Related Research Area

AXIN1 involved in several pathways and played different roles in them. We selected most pathways AXIN1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with AXIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayDAAM1;ROCK2A;RAC1;BTRC;WNT9B;SOST;TRP53;FOSL1;MAP3K7
Hippo signaling pathwayID1;WTIP;FZD10;BMP2;BMPR1B;CDH1;PRKCZ;SERPINE1;LLGL2
Signaling pathways regulating pluripotency of stem cellsMYF5;ISL1;ESRRB;WNT8B;WNT3;SOX2;FZD2;PIK3R3;WNT11
Pathways in cancerFGFR3;CASP9;FOS;FZD9;PTGER2;SPI1;BDKRB1;LAMA2;CYCS
Colorectal cancerRAC1;MAPK1;MLH1;MAPK3;TCF7L2;RALGDS;AKT1;BRAF;TCF7
Endometrial cancerAXIN1;MAP2K2;MAP2K1;AKT1;PIK3CG;TCF7L2;PIK3R3;ELK1;PIK3CB
Basal cell carcinomaPTCH1;FZD5;HHIP;FZD1;WNT8B;GLI3;TP53;WNT7A;WNT2

AXIN1 has several biochemical functions, for example, GTPase activator activity, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AXIN1 itself. We selected most functions AXIN1 had, and list some proteins which have the same functions with AXIN1. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityGDI2;SRGAP3;WNT11;CDC42EP5;TBC1D19;ARHGAP31;EVI5L;TBC1D10A;RGS14A
I-SMAD bindingSMAD6;AXIN2;SMAD1;SMURF1;TGFBR1;SMAD4;CTNNB1;SMAD2;SMAD7
R-SMAD bindingPARP1;MYOCD;ANKRD1;TRIM33;SMAD4;SMURF1;SMAD2;C18orf1;SMAD3
SMAD bindingYY1;FLNA;EP300;PURA;TOB1;TGFBRAP1;HMGA2;SMAD2;TGFBR1
armadillo repeat domain bindingCALCOCO1;CHD8;CNOT1;LEF1;AXIN2;CTNNBIP1;STRN;TCF7L2;STRN4
beta-catenin bindingAr;PTPRJ;PROP1;DACT2;TCF7L1A;NUMB;TBL1X;C;SOX9
enzyme bindingCFTR;HOXA9;HMOX1;HDAC1;MARCH6;SPDL1;NLRP1;EGFR;PLAUR
identical protein bindingPITX2;POLG2;SMAD6;ETNPPL;DESI1;TARDBP;VIM;SMG9;POU3F2
p53 bindingBRD7;RNF20;CDK5;STK11;RFFL;CHD8;RFWD3;ZNF385B;DUSP26
protein C-terminus bindingSIAH1A;PPP1R9B;MID1IP1;ATP1B1;PQBP1;PCGF1;ERCC4;SLC4A1;SHANK2
protein bindingTMPRSS4;ARHGEF38;TIPIN;DZIP1L;OPRK1;ODF1;AGXT;LGALS9C;Ntng2
protein complex scaffoldMPP7;CAV1;WWC3;AKAP6;AKAP9;ITSN1;AXIN1;AKAP1;SMARCD1
protein homodimerization activityGRPEL2;SP100;GHR;CHRNA7;NKX2-5;TRPM8;PDGFA;TGFB2;CAMK2A
protein kinase bindingCALM2;YWHAZ;GSTP2;EEF1A2;EMP2;EEF1A1;SLC12A4;PARN;IBTK
protein self-associationAXIN1;SHANK3;CNTN2;ABCD3;BCL10;NKX3-1;ZFP639;RYR2;AGTR1A
receptor signaling complex scaffold activityGRIP1;NUP62;NCK1;MMS19;CARD10;NCK2;G3BP2;ROPN1B;LDLRAP1
signal transducer activityNPY8BR;CNOT7;VMN1R48;OLFR480;OMP;MRGPRH;MGAA;TMTOPS2B;TRADD
ubiquitin protein ligase bindingUBE2G1;TSG101;RELA;ERLIN2;RNF31;UQCRC1;TP53;BAG6;MAGEC2

AXIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AXIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AXIN1.

GSK3B

Valenti, F; Ibetti, J; et al. The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype. JOURNAL OF CELLULAR BIOCHEMISTRY 116:418-430(2015).
Siwek, M; Slawinska, A; et al. A quantitative trait locus for a primary antibody response to keyhole limpet hemocyanin on chicken chromosome 14-Confirmation and candidate gene approach. POULTRY SCIENCE 89:1850-1857(2010).
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