Recombinant Human IMPDH2, MYC/DDK-tagged IMPDH2-1276H

Recombinant Human IMPDH2, MYC/DDK-tagged


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Recombinant Human IMPDH2, MYC/DDK-tagged

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Cat.No. : IMPDH2-1276H
Product Overview : Recombinant Human IMPDH2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description : This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Source : HEK293 cells
Species : Human
Molecular Mass : 55.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 [ Homo sapiens (human) ]
Official Symbol : IMPDH2
Synonyms : IMPDH2; IMPDH 2; IMPD2; IMPD 2; IMP (inosine 5"-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMPDH-II; IMP oxireductase 2; inosine 5" phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; IMP dehydrogenase 2; inosine-5"-monophosphate dehydrogenase 2; IMP dehydrogenase 2; EC; OTTHUMP00000210556
Gene ID : 3615
mRNA Refseq : NM_000884
Protein Refseq : NP_000875
MIM : 146691
UniProt ID : P12268
Chromosome Location : 3p21.2
Pathway : Drug metabolism - other enzymes; Metabolic pathways; Purine metabolism; Purine ribonucleoside monophosphate biosynthesis
Function : IMP dehydrogenase activity; metal ion binding; nucleotide binding; oxidoreductase activity; protein binding

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