Recombinant Human IMPDH2, MYC/DDK-tagged

• Cat.No.: IMPDH2-1276H
• Product Overview: Recombinant Human IMPDH2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Molecular Mass: 55.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 [ Homo sapiens (human) ]
• Official Symbol: IMPDH2
• Synonyms: IMPDH2; IMPDH 2; IMPD2; IMPD 2; IMP (inosine 5"-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMPDH-II; IMP oxireductase 2; inosine 5" phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; IMP dehydrogenase 2; inosine-5"-monophosphate dehydrogenase 2; IMP dehydrogenase 2; EC 1.1.1.205; OTTHUMP00000210556
• Gene ID: 3615
• mRNA Refseq: NM_000884
• Protein Refseq: NP_000875
• MIM: 146691
• UniProt ID: P12268
• Chromosome Location: 3p21.2
• Pathway: Drug metabolism - other enzymes; Metabolic pathways; Purine metabolism; Purine ribonucleoside monophosphate biosynthesis
• Function: IMP dehydrogenase activity; metal ion binding; nucleotide binding; oxidoreductase activity; protein binding