"IL15RA" Related Products


Recombinant Human IL15RA protein, Fc-tagged

Cat.No.: IL15RA-1655H
Product Overview: Recombinant Human IL15RA(Met1 - Thr205) fused with Fc region of Human IgG1 at C-terminal was expressed in HEK293.
Description: Interleukin 15 Receptor alpha (IL-15 R alpha ), also known as CD215, is a widely expressed 60 kDa transmembrane glycoprotein that plays an important role in the homeostasis and activation of NK cells and CD8+ memory T cells and participates in the development and function of many other hematopoietic cell types and non-immune cell types. Mature human IL-15 R alpha consists of a 175 aa extracellular domain (ECD) containing one N-linked glycosylation site, a 23 aa transmembrane segment, and a 39 aa cytoplasmic tail. Within the ECD, human IL-15 R alpha shares approximately 60% aa sequence identity with mouse and rat IL-15 R alpha. Alternate splicing of human IL-15 R alpha generates additional isoforms with variable length deletions in the ECD and/or substitutions in the cytoplasmic domain. IL-15 R alpha binds to Interleukin-15 with high affinity. IL-15 additionally interacts with lower affinity to a complex of IL-2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL-2 receptor complex. The use of shared receptor components contributes to the overlapping biological effects of IL-15 and IL-2. The dominant mechanism of IL-15 action is known as transpresentation in which IL-15/IL-15 R alpha complexes are expressed on the surface of one cell and interact with complexes of IL-2 R beta / gamma c on adjacent cells. This enables cells to respond to IL-15 even if they do not express IL-15 R alpha. IL-15/IL-15 R alpha complexes can transmit reverse signaling that promotes cellular adhesion, tyrosine phosphorylation of intracellular proteins, and cytokine secretion by the IL-15/IL-15 R alpha expressing cells. Shed soluble forms of IL-15 R alpha retain the ability to bind tightly to IL-15 and can inhibit IL-15 bioactivity.
Source: HEK293
Species: Human
Tag: Fc
Predicted N Terminal: Ile31
Form: Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity: The ED50 for this effect is typically 2-10 ng/mL.
Molecular Mass: Predicted Molecular Mass: 45 (monomer) kDa;SDS-PAGE: 75-90 kDa, reducing conditions.
Endotoxin: <0.01 EU per 1 μg of the protein by the LAL method.
Storage: Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution: Reconstitute at 100 μg/mL in PBS.
Gene Name: IL15RA interleukin 15 receptor, alpha [ Homo sapiens ]
Official Symbol: IL15RA
Synonyms: IL15RA; interleukin 15 receptor, alpha; interleukin-15 receptor subunit alpha; CD215; IL 15RA; MGC104179;
Gene ID: 3601
mRNA Refseq: NM_001243539
Protein Refseq: NP_001230468
MIM: 601070
UniProt ID: Q13261
Chromosome Location: 10p15.1
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem;
Function: cytokine receptor activity; protein binding; receptor activity; signal transducer activity;

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