Active Recombinant Human IL15RA Homodimer Protein, His&Avi tagged

• Cat.No.: IL15RA-49H
• Product Overview: IL-15Rα dimer protein contains an IL-15Rα extracellular domain (UniProt# Q13261) fused with a dimer motif followed by a tandem His-Avi tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 31-205 aa
• Description: Human interleukin 15 receptor alpha subunit (IL-15Rα) is a transmembrane cytokine receptor. IL-15Rα is also known as IL-15Ra, IL15Ra, cluster of differentiation 215 (CD215), and interleukin 15 receptor subunit alpha. IL-15Rα contains an extracellular domain with a single sushi domain (short consensus repeat or complement control protein repeat), which is essential for interleukin 15 (IL-15) binding and IL-15Rα function, a linker/hinge region, and a membrane-proximal proline-threonine-rich region followed by a transmembrane domain, and cytoplasmic domain. IL-15Rα can homodimerize as well as heterodimerize with IL-2Rβ/CD122 and IL-2Rγ/CD132. IL-15Rα specifically binds IL-15 with very high affinity and is capable of binding IL-15 independently of other subunits. IL-15 stimulations of NK cells and T-cells has been shown to sustain long-lasting antitumor immunity, making IL-15Rα an attractive therapeutic target for immunotherapies.
• Molecular Mass: 57 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for IL-15Rα-specific antibody and interleukin 15 (IL-15) ligand protein binding assays. Suggested Applications: SPR & BLI for IL-15Rα-specific antibody and IL-15 protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: IL15RA interleukin 15 receptor, alpha [ Homo sapiens (human) ]
• Official Symbol: IL15RA
• Synonyms: IL15RA; interleukin 15 receptor, alpha; interleukin-15 receptor subunit alpha; CD215; IL 15RA; MGC104179
• Gene ID: 3601
• mRNA Refseq: NM_001243539
• Protein Refseq: NP_001230468
• MIM: 601070
• UniProt ID: Q13261