Active Recombinant Mouse IL15RA Protein, His-tagged

• Cat.No.: IL15RA-73M
• Product Overview: IL-15Rα protein dimer contains an IL-15Rα extracellular domain (UniProt# Q60819) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus.

Specification

• Species: Mouse
• Source: HEK293T
• Tag: His
• Protein Length: 33-205 aa
• Description: Interleukin 15 receptor alpha subunit (IL-15Rα) is a transmembrane cytokine receptor. IL-15Rα is also known as IL-15Ra, IL15Ra, cluster of differentiation 215 (CD215), and interleukin 15 receptor subunit alpha. IL-15Rα contains an extracellular domain with a single sushi domain (short consensus repeat or complement control protein repeat), which is essential for interleukin 15 (IL-15) binding and IL-15Rα function, a linker/hinge region, and a membrane-proximal proline-threonine-rich region followed by a transmembrane domain, and cytoplasmic domain. IL-15Rα can homodimerize as well as heterodimerize with IL-2Rβ/CD122 and IL-2Rγ/CD132. IL-15Rα specifically binds IL-15 with very high affinity and is capable of binding IL-15 independently of other subunits. IL-15 stimulations of NK cells and T-cells has been shown to sustain long-lasting antitumor immunity, making IL-15Rα an attractive therapeutic target for immunotherapies. Mouse IL-15Rα, the murine homolog of human IL-15Rα with conserved structural domains, is a species-specific tool essential for basic research, translational research and preclinical studies.
• Molecular Mass: 53 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for IL-15Rα-specific antibody and interleukin 15 (IL-15) ligand protein binding assays. Suggested Applications: SPR & BLI for IL-15Rα-specific antibody and IL-15 protein binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.2μm filtered PBS, pH 7.4, no preservatives
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name 2: Il15ra interleukin 15 receptor, alpha chain [ Mus musculus (house mouse) ]
• Official Symbol 2: Il15ra
• Synonyms 2: IL15RA; interleukin 15 receptor, alpha chain; interleukin-15 receptor subunit alpha; IL-15RA; IL-15R-alpha; IL-15 receptor subunit alpha; AA690181
• Gene ID 2: 16169
• mRNA Refseq 2: NM_008358
• Protein Refseq 2: NP_032384
• UniProt ID 2: Q8R5E4