"FGFR1" Related Products

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Recombinant Human FGFR1, His-tagged

Cat.No.: FGFR1-18H
Product Overview: Recombinant Human FGFR1(Arg 22 - Ile 376), fused with a polyhistidine tag at the C-terminus, was expressed in human 293 cells.
Description: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Source: HEK293
Species: Human
Tag: His
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Bio-activity: Measured by its binding ability in a functional ELISA.Immobilized Human FGFR1 /CD331 Protein at 5 µg/mL (100 µl/well) can bind Biotinylated Human bFGF Protein. The EC50 is typically 1.17 µg/mL
Molecular Mass: rh FGFR1 is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 42.5 kDa. The predicted N-terminus is Arg 22. DTT-reduced Protein migrates as 60-65 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rh FGFR1 by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name: FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens (human) ]
Official Symbol: FGFR1
Synonyms: FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; FGFR1/PLAG1 fusion; FMS-like tyrosine kinase 2; basic fibroblast growth factor receptor 1; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; proto-oncogene c-Fgr; NP_001167534.1; EC 2.7.10.1; NP_001167535.1; NP_001167536.1; NP_001167537.1; NP_001167538.1; NP_056934.2; NP_075593.1NP_075593.1; NP_075598.2
Gene ID: 2260
mRNA Refseq: NM_001174063
Protein Refseq: NP_001167534
MIM: 136350
UniProt ID: P11362
Chromosome Location: 8p11.23-p11.22
Pathway: Adaptive Immune System; Central carbon metabolism in cancer; DAP12 interactions
Function: fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; heparin binding

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