Active Recombinant Human FGFR1 Protein, His&Avi tagged

• Cat.No.: FGFR1-67H
• Product Overview: FGFR1 dimer protein contains a FGFR1 extracellular domain (UniProt# P11362) fused with a proprietary dimer motif followed by a tandem His-Avi tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 22-376 aa
• Description: Human fibroblast growth factor receptor 1 (FGFR1) is a cell surface receptor belonging to the immunoglobulin superfamily and a transmembrane receptor tyrosine kinase (RTK) that belongs to the FGFR family. FGFR1 is also known as basic fibroblast growth factor receptor 1 (BFGFR), cluster of differentiation 331 (CD331), CEK, FGFBR, FLG, Fms-like tyrosine kinase 2 (FLT-2), HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, and ECCL. FGFR1, a Type I transmembrane protein, contains an extracellular domain with three immunoglobulin-like (Ig-like) subdomains (D1, D2 and D3), followed by a transmembrane, and an intracellular domain. Dimerization of FGFRs is necessary for activation and they can homodimerize and heterodimerize in both the presence and absence of ligand. FGFRs bind fibroblast growth factors (FGFs) leading to phosphorylation and triggering signaling cascades. FGFR1 overexpression has been reported in a variety of cancers including up to 22% of non-small-cell lung carcinoma, 14% of urinary bladder transitional cell carcinomas, 10% of estrogen receptor positive breast cancers, and 10% of squamous cell head and neck cancers. Ligand-independent FGFR1 dimerization is an important driver of hematologic malignancies, solid tumors, and developmental disorders. Inhibition of FGFRs has been an emerging target for cancer therapeutics, therefore, a recombinant protein mimicking the FGFR1 dimer conformation can be critical for cancer therapeutic discovery.
• Molecular Mass: 99 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for FGFR1-specific antibody and BLI for fibroblast growth factor 1 (FGF-1) ligand protein binding assays. Suggested Applications: SPR for FGFR1-specific antibody and FGF-1 protein binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name 2: FGFR1 fibroblast growth factor receptor 1 [Homo sapiens (human)]
• Official Symbol 2: FGFR1
• Synonyms 2: FGFR1; fibroblast growth factor receptor 1; FLT2, fms related tyrosine kinase 2, KAL2; BFGFR; CD331; CEK; FLG; H2; H3; H4; H5; N SAM; Pfeiffer syndrome; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; OGD; FLT2; KAL2; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; bFGF-R-1; FLJ99988
• Gene ID 2: 2260
• mRNA Refseq 2: NM_001174063
• Protein Refseq 2: NP_001167534
• MIM 2: 136350
• UniProt ID 2: P11362