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Recombinant Human FASLG protein, His-tagged

Cat.No. : FASLG-46H
Product Overview : Recombinant Human FASLG protein (Pro134-Leu281), fused to His tag at N-terminus, was expressed in human 293 cells (HEK293).
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  • Gene Information
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Description : Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 17.7 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 148
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : FASLG
Official Symbol : FASLG
Synonyms : FASLG; Fas ligand (TNF superfamily, member 6); APT1LG1, TNFSF6, tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand superfamily member 6; CD178; FasL; APTL; CD95 ligand; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6; FASL; CD95L; CD95-L; TNFSF6; APT1LG1
Gene ID : 356
mRNA Refseq : NM_000639
Protein Refseq : NP_000630
MIM : 134638
UniProt ID : P48023

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there diagnostic tests that measure FASLG levels in clinical settings? 06/27/2019

Yes, there are diagnostic tests that measure FASLG levels, which can provide insights into immune function and disease processes.

In what ways can the FASLG protein be targeted for therapeutic purposes? 11/29/2018

The FASLG protein can be targeted for therapeutic purposes in cancer treatment and autoimmune disease management.

How is the FASLG protein involved in the pathogenesis of liver diseases? 09/17/2018

Dysregulation of FASLG expression can contribute to liver injury and the progression of liver diseases such as hepatitis and liver fibrosis.

How does the FASLG protein contribute to the pathogenesis of inflammatory bowel disease? 01/11/2018

Dysregulation of FASLG expression can impact intestinal immune homeostasis and contribute to the pathogenesis of inflammatory bowel disease.

What role does the FASLG protein play in organ transplantation? 01/17/2016

FASLG is involved in the regulation of immune responses to transplanted organs, and its dysregulation can impact transplant outcomes.

Customer Reviews (3)

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Reviews
06/06/2021

    The outstanding level of customer service adds extra reassurance and confidence in using the FASLG protein for my scientific investigations.

    06/20/2018

      the manufacturer of FASLG provides exceptional technical support, offering valuable assistance in troubleshooting and experimental design.

      08/28/2017

        The FASLG protein surpasses expectations in terms of quality and will undoubtedly fulfill my experimental requirements.

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