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Recombinant Human CCL25

Cat.No.: CCL25-31213TH
Product Overview: Recombinant mature Human TECK. 127 amino acids with a predicted MWt 14.2 kDa.
Description: This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants.
Protein length: 127 amino acids
Molecular Weight: 14.200kDa
Source: E. coli
Tissue specificity: Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.
Biological activity: Determined by its ability to chemoattract Human monocytes using a concentration range of 1-10ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.
Form: Lyophilised:It is recommended to reconstitute CCL25-31213TH in sterile 18MO-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Purity: by SDS-PAGE
Storage buffer: pH: 7.40Constituents:0.28% Phosphate Buffer, 0.88% Sodium chloride
Storage: Please see Notes section
Sequences of amino acids: QGVFEDCCLA YHYPIGWAVL RRAWTYRIQE VSGSCNLPAA IFYLPKRHRK VCGNPKSREV QRAMKLLDAR NKVFAKLHHN MQTFQAGPHA VKKLSSGNSK LSSSKFSNPI SSSRKNVSLL ISANSGL
Sequence Similarities: Belongs to the intercrine beta (chemokine CC) family.
Gene Name: CCL25 chemokine (C-C motif) ligand 25 [ Homo sapiens ]
Official Symbol: CCL25
Synonyms: CCL25; chemokine (C-C motif) ligand 25; SCYA25, small inducible cytokine subfamily A (Cys Cys), member 25; C-C motif chemokine 25; Ck beta 15; Ckb15; TECK; TECKvar; thymus expressed chemokine;
Gene ID: 6370
mRNA Refseq: NM_001201359
Protein Refseq: NP_001188288
MIM: 602565
Uniprot ID: O15444
Chromosome Location: 19p13.2
Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;
Function: CCR10 chemokine receptor binding; chemokine activity; hormone activity;

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