Recombinant Human CLIC1, His-tagged

• Cat.No.: CLIC1-27816TH
• Product Overview: Recombinant full-length Human CLIC1 with N terminal His tag, amino acids 1-241, 261 amino acids with tag, MWt 29 kDa,

Specification

• Description: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expression is prominent in heart, placenta, liver, kidney and pancreas.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, pH 8
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYGTEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDEGVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K
• Sequence Similarities: Belongs to the chloride channel CLIC family.Contains 1 GST C-terminal domain.

Gene Information

• Gene Name: CLIC1 chloride intracellular channel 1 [ Homo sapiens ]
• Official Symbol: CLIC1
• Synonyms: CLIC1; chloride intracellular channel 1; chloride intracellular channel protein 1; NCC27; p64CLCP
• Gene ID: 1192
• mRNA Refseq: NM_001288
• Protein Refseq: NP_001279
• MIM: 602872
• Uniprot ID: O00299
• Chromosome Location: 6p21.3
• Function: chloride channel activity; protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity