Recombinant Human CLIC1, His-tagged

Cat.No. : CLIC1-27814TH
Product Overview : Recombinant full length, Human CLIC1 (amino acids 1-241) with N terminal His tag; 261 amino acids, with a predicted MWt 29 kDa including tag.
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Description : Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
Protein length : 241 amino acids
Conjugation : HIS
Molecular Weight : 29.000kDa inclusive of tags
Source : E. coli
Tissue specificity : Expression is prominent in heart, placenta, liver, kidney and pancreas.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 0.58% Sodium chloride, 10% Glycerol
Storage : Store at -20°C (dessicate conditions).
Sequences of amino acids : GSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K
Sequence Similarities : Belongs to the chloride channel CLIC family.Contains 1 GST C-terminal domain.
Gene Name : CLIC1 chloride intracellular channel 1 [ Homo sapiens ]
Official Symbol : CLIC1
Synonyms : CLIC1; chloride intracellular channel 1; chloride intracellular channel protein 1; NCC27; p64CLCP;
Gene ID : 1192
mRNA Refseq : NM_001288
Protein Refseq : NP_001279
MIM : 602872
Uniprot ID : O00299
Chromosome Location : 6p21.3
Function : chloride channel activity; protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does CLIC1 protein contribute to cancer progression? 08/26/2021

CLIC1 protein promotes cancer cell proliferation, migration, and invasion, making it a potential target for cancer therapy.

Are there any clinical trials targeting CLIC1 protein in cancer therapy? 07/23/2021

Several clinical trials are investigating the efficacy of CLIC1 protein-targeted therapies in various types of cancer, including breast, lung, and colorectal cancer.

How does CLIC1 protein contribute to cardiovascular disorders? 12/09/2020

CLIC1 protein has been linked to cardiac hypertrophy, fibrosis, and arrhythmias, suggesting its involvement in the pathogenesis of cardiovascular diseases.

Can CLIC1 protein be used as a therapeutic target in neurodegenerative diseases? 12/01/2018

Yes, targeting CLIC1 protein has shown promise in preclinical studies as a potential therapeutic approach for neurodegenerative diseases.

How is CLIC1 protein involved in neurodegenerative diseases? 09/20/2017

CLIC1 protein has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's, where it may play a role in neuronal dysfunction and neuroinflammation.

Customer Reviews (3)

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12/12/2022

    With the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.

    07/26/2020

      Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.

      11/04/2018

        Researchers who have utilized the CLIC1 protein laud its reliability and effectiveness in their studies.

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