||SolubleEGFR human recombinant fragment, produced in baculovirus/Sf9 insect cells, is a monomeric, glycosylated, polypeptide chain and has a molecular mass of 80 kDa.
||The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
||Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
||Lyophilised:Reconstitute the lyophilized EGFR in sterile PBS not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
||>90% by SDS-PAGE
||Preservative: NoneConstituents: PBS, pH 7.4
||Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
||Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.Contains 1 protein kinase domain.