Recombinant HumanEpidermal Growth Factor Receptor

• Cat.No.: EGFR-P1001H
• Product Overview: Recombinanthuman EGFR fused with a his tag was produced in Chinese hamster somatic cellsR1610.

Specification

• Cat. No.: EGFR-P1001H
• Description: EpidermalGrowth Factor Receptor is known as HER1 and is a member of the so-called HERfamily of receptors or the epidermal growth factor "super-family."The HER family receptors including HER1, HER2, HER3, and HER4 arecharacterized by partnerships or couplings between individual family members.For example, the HER1/HER2 coupling (dimer) is felt to be the most importantstimulus for breast cancer growth in HER2-positive breast cancers.
• ProteinConstruction: Recombinanthuman EGFR is combined the Sequence of EGFR and 6His.
• Source: Chinese hamster somatic cells R1610
• Purity: >95% as determined by SDS-PAGE andHPLC
• Endotoxin: <1.0EU per 10 mg protein as determined by the LAL method
• Stability: Samples arestable for up to six months from date of receipt at -20℃ and are stable fortwo months at 4℃.
• Molecular Mass: Recombinant humanEGFR contains 621 amino acid residues, combining 6His, The MW is about 95kDa.
• Predicted N terminal: LEEKKVCQGTS
• Formulation: Normally 20-50mMNaAC-HAC and 100-150 mM NaCl are added, pH 5.0-6.0.
• Storage: Store itunder sterile conditions at -70℃uponreceiving. Recommend to pack the protein into smaller quantities for optimalstorage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: EGFRepidermal growth factor receptor [ Homo sapiens ]
• Official Symbol: EGFR
• Synonyms: EGFR; epidermal growthfactor receptor; ERBB; ERBB1; mENA; HER1; PIG61; Receptor tyrosine-proteinkinase erB-1; Proto-oncogene c-ErbB-1; epidermal growth factor receptor(avian erythroblastic leukemia viral (v-erb-b) oncogene homolog);OTTHUMP00000209210; cell growth inhibiting protein 40; epidermal growthfactor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog,avian); cell proliferation-inducing protein 61; avian erythroblastic leukemiaviral (v-erb-b) oncogene homolog; erythroblastic leukemia viral (v-erb-b)oncogene homolog; EC. 2.7.10.1
• Gene ID: 1956
• mRNA Refseq: NM_005228
• Protein Refseq: NP_005219
• MIM: 131550
• UniProt ID: Q9GZX1
• Chromosome Location: 7p12
• Pathway: Adherens junction;Bladder cancer; Calcium signaling pathway; Cytokine-cytokine receptorinteraction; Dorso-ventral axis formation; Endocytosis; Endometrial cancer
• Function: ATP binding; MAPK/ERKkinase kinase activity; enzyme binding