egfr Protein, epidermal growth factor receptor

egfr

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egfr

Official Full Name epidermal growth factor receptor
Background The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Synonyms EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; ERBB; HER1; mENA; PIG61
    • Species :
    • Canine
    • Chicken
    • Cynomolgus Monkey
    • E.coli
    • Human
    • Mouse
    • Rat
    • Rhesus
    • Rhesus macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • Mouse
    • NS0
    • Rabbit
    • Sf9
    • Sf9 Insect Cell
    • Tag :
    • Avi
    • His
    • DDK
    • Fc
    • Fc Chimera
    • Flag
    • GST
    • HIgG1 Fc
    • HIgG
    • S
    • T7
    • human
    • IgG1
    • Myc
    • N/A
    • Strep
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EGFR-389H Recombinant Human EGFR protein, GST-tagged Insect cells GST
    Human EGFR-49H Recombinant Human EGFR protein, GST-tagged Insect cells GST
    Human EGFR-9938H Recombinant Human EGFR protein, GST-tagged Sf9 GST
    Human EGFR-017M EGFR-coupled magnetic beads
    Human EGFR-024HA Recombinant Human EGFR protein, Fc-tagged, APC labeled HEK293 Fc
    Human EGFR-024HP Recombinant Human EGFR protein, Fc-tagged, R-PE labeled HEK293 Fc
    Mouse EGFR-102MA Recombinant Mouse EGFR protein, Fc-tagged, APC labeled HEK293 Fc
    Mouse EGFR-102MP Recombinant Mouse EGFR protein, Fc-tagged, R-PE labeled HEK293 Fc
    Rhesus EGFR-1226RA Recombinant Rhesus EGFR protein, Fc-tagged, APC labeled HEK293 Fc
    Rhesus EGFR-1226RP Recombinant Rhesus EGFR protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human EGFR-28395THA Recombinant Human EGFR protein, Fc-tagged, APC labeled HEK293 Fc
    Human EGFR-28395THP Recombinant Human EGFR protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human EGFR-288H Recombinant Human EGFR Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human EGFR-337H Recombinant Human EGFRvIII Protein (Leu 25 - Ser 645), His-tagged HEK293 His
    Human EGFR-338H Recombinant Human EGFR Protein (Leu 25 - Ser 645), His-tagged, low endotoxin HEK293 His
    Human EGFR-339H Recombinant Human EGFR Protein (Leu 25 - Ser 645), Fc-tagged HEK293 Fc
    Human EGFR-340H Recombinant Human EGFR Protein, Strep-tagged HEK293 Strep
    Human EGFR-341H Recombinant Human EGFRvIII Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human EGFR-464HA Recombinant Human EGFR protein, Fc-tagged, APC labeled NS0 Fc
    Human EGFR-464HP Recombinant Human EGFR protein, Fc-tagged, R-PE labeled NS0 Fc
    Human EGFR-629HA Recombinant Human EGFR protein, Fc-tagged, APC labeled HEK293 Fc
    Human EGFR-629HP Recombinant Human EGFR protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human EGFR-689H Recombinant Human EGFR Protein (Met1-Lys375) (Isoform vIII), HIgG1 Fc-tagged Insect Cell HIgG1 Fc
    Human EGFR-690H Recombinant Human EGFR Protein (Met1-Lys375) (Isoform vIII), His-tagged Insect Cell His
    Human EGFR-692HA Recombinant Human EGFR protein, Fc-tagged, APC labeled HEK293 Fc
    Human EGFR-692HP Recombinant Human EGFR protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human CAB-11472MH Mouse Anti-Human EGFR Monoclonal Antibody Mouse N/A
    Human CAB11527MH Mouse Anti-Human Epidermal Growth Factor Receptor Monoclonal Antibody Mouse N/A
    Human CAB11528RH Rabbit Anti-Human Epidermal Growth Factor Receptor Monoclonal Antibody Rabbit N/A
    Human CSC-H0002 Mouse Anti-Human EGFR Hybridoma N/A
    Human EGFR-024H Recombinant Human EGFR Protein, Fc-tagged HEK293 Fc
    Human EGFR-025H Recombinant Human EGFR Protein, His-tagged HEK293 His
    Human EGFR-1211H Recombinant Human Epidermal Growth Factor Receptor, GST-tagged Sf9 Insect Cell GST
    Human EGFR-1369H Recombinant Human EGFR Protein, DDK-tagged Insect Cell DDK
    Human EGFR-1373H Recombinant Human EGFR Protein, His-tagged Insect Cell His
    Human EGFR-1399H Recombinant Human EGFR (Active), GST-tagged Sf9 Insect Cell GST
    Human EGFR-155H Recombinant Human EGFR Protein, His-tagged, Active Insect Cell His
    Human EGFR-182H Recombinant Human EGFR (C797S L858R) protein, GST-tagged, Active Insect Cell GST
    Human EGFR-183H Recombinant Human EGFR(L858R) protein, GST-tagged, Active Insect Cell GST
    Human EGFR-184H Recombinant Human EGFR(T790M C797S)protein, GST-tagged, Active Insect Cell GST
    Human EGFR-186H Recombinant Human EGFR (T790M) protein, GST-tagged, Active Insect Cell GST
    Human EGFR-193H Recombinant Human EGFR protein, DDK/His-tagged HEK293 DDK/His
    Human EGFR-194H Recombinant Human EGFR protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EGFR-195H Recombinant Human EGFR protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EGFR-196H Recombinant Human EGFR protein, His-tagged Insect Cell His
    Human EGFR-197H Recombinant Human EGFR protein, DDK-tagged Insect Cell DDK
    Human EGFR-198H Recombinant Human ABCB5 protein, DDK-tagged Insect Cell DDK
    Human EGFR-201H Recombinant Human EGFR protein CHO N/A
    Human EGFR-202H Recombinant Human EGFR Protein, His-tagged CHO His
    Human EGFR-206H Recombinant Human EGFR, His-tagged HEK293 His
    Human EGFR-22H Recombinant Human EGFR protein, His/T7-tagged E.coli His/T7
    Human EGFR-230H Recombinant Human EGFR, StrepII-tagged Human Cell Strep II
    Human EGFR-233H Recombinant Human EGFR, Strep-tagged Sf9 Insect Cell Strep II
    Human EGFR-2733HCL Recombinant Human EGFR cell lysate Human Cell N/A
    Human EGFR-28392TH Recombinant Human EGFR N/A
    Human EGFR-28395TH Recombinant Human EGFR, Fc-tagged Fc
    Human EGFR-28468TH Recombinant Human EGFR N/A
    Human EGFR-284H Recombinant Human EGFR, His-tagged, Biotinylated HEK293 His
    Human EGFR-285H Recombinant Human EGFR, His&Avi-tagged, Biotinylated HEK293 His/Avi
    Human EGFR-286H Recombinant Human EGFR protein, His-tagged HEK293 His
    Human EGFR-287H Recombinant Human EGFR protein, Avi/His-tagged, Biotinylated HEK293 Avi/His
    Human EGFR-297H Recombinant Human EGFR, GST-tagged, Active Sf9 Insect Cell GST
    Human EGFR-29H Recombinant Human Epidermal Growth Factor Receptor Sf9 Insect Cell N/A
    Human EGFR-30H Recombinant Human EGFR, His tagged Human Cell His
    Human EGFR-31H Recombinant Human EGFR, His-GST tagged Insect Cell His/GST
    Human EGFR-33H Recombinant Human EGFR protein, GST-tagged Insect Cell GST
    Human EGFR-3803H Recombinant Human EGFR, His tagged Insect Cell His
    Human EGFR-39H Recombinant Human EGFR Mutant (d747-752 P753S), GST-tagged Sf9 Insect Cell GST
    Human EGFR-40H Recombinant Human EGFR Mutant (G719C), GST-tagged Sf9 Insect Cell GST
    Human EGFR-41H Recombinant Human EGFR Mutant (G719S), GST-tagged Sf9 Insect Cell GST
    Human EGFR-42H Recombinant Human EGFR protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human EGFR-43H Recombinant Human EGFR(T790M/L858R) protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human EGFR-463H Recombinant Human EGFR NS0 N/A
    Human EGFR-464H Recombinant Human EGFR, Fc Chimera NS0 Fc Chimera
    Human EGFR-4753H Recombinant Human Epidermal Growth Factor Receptor, His-tagged Human His
    Human EGFR-55H Recombinant Human EGFR protein, hIgG-His-tagged CHO His/HIgG
    Human EGFR-602H Recombinant Human EGFR, Fc-tagged, Biotinylated Human Cell Fc
    Human EGFR-625H Recombinant Human EGFR protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EGFR-628H Recombinant Human EGFR protein, His-tagged HEK293 His
    Human EGFR-629H Recombinant Human EGFR protein, Fc-tagged HEK293 Fc
    Human EGFR-663HCL Recombinant Human EGFR cell lysate Insect Cell N/A
    Human EGFR-692H Recombinant Human EGFR, Fc Chimera HEK293 Fc
    Human EGFR-7629H Recombinant Human EGFR protein, His & S-tagged E.coli His/S
    Human EGFR-893H Recombinant Human Epidermal Growth Factor Receptor, Strep-tagged Human N/A
    Human EGFR-P1001H Recombinant HumanEpidermal Growth Factor Receptor CHO N/A
    Mouse EGFR-100M Recombinant Mouse EGFR Protein, His-tagged HEK293 His
    Mouse EGFR-101M Recombinant Mouse EGFR, His tagged Human Cell His
    Mouse EGFR-102M Recombinant Mouse EGFR, Fc tagged Human Cell Fc
    Mouse EGFR-1621MCL Recombinant Mouse EGFR cell lysate Human Cell N/A
    Mouse Egfr-202M Recombinant Mouse Egfr protein, His/S-tagged E.coli His/S
    Mouse Egfr-5224M Recombinant Mouse Egfr protein, His-tagged HEK293 His
    Mouse Egfr-7630M Recombinant Mouse Egfr protein, His & T7-tagged E.coli His/T7
    Rat EGFR-1462RCL Recombinant Rat EGFR cell lysate Human Cell N/A
    Rat Egfr-203R Recombinant Rat Egfr protein, His/S-tagged E.coli His/S
    Rat Egfr-7433R Recombinant Rat Egfr, His-tagged Human Cell His
    Cynomolgus Monkey EGFR-60C Recombinant Cynomolgus EGFR protein, His-tagged Insect Cell His
    Rhesus macaque EGFR-61C Recombinant Rhesus macaque EGFR protein, His-tagged HEK293 His
    Rhesus macaque EGFR-1226R Recombinant Rhesus macaque EGFR protein, Fc-tagged HEK293 human/IgG1/Fc
    Rhesus Macaque EGFR-1227R Recombinant Rhesus EGFR Protein, His-tagged Insect Cell His
    Rhesus Macaque EGFR-1228R Recombinant Rhesus EGFR Protein, His-tagged HEK293 His
    Canine EGFR-168C Recombinant Canine EGFR, His-tagged Insect Cell His
    Chicken EGFR-7046C Recombinant Chicken EGFR Mammalian Cell His
    E.coli EGFR-1374E Recombinant E. coli EGFR Protein, His-tagged E.coli His

    egfr involved in several pathways and played different roles in them. We selected most pathways egfr participated on our site, such as AGE/RAGE pathway, ARMS-mediated activation, Adaptive Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with egfr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AGE/RAGE pathway MAPK14; JAK2; TIRAP; CHUK; EGFR; JUN; DDOST; DIAPH1; LGALS3; AGER
    ARMS-mediated activation SPNA2; DUSP9; CSF2; RASGRP1; FRS2B; PSMD9; FGF10B; MARK3; LAMTOR2; SPRED1
    Adaptive Immune System GRAP2B; WSB1; SIGLEC9; ASB7; KIF2B; KIF5B; AKT3; NCR3LG1; DNM2; SPSB2
    Adherens junction EGFR; VCL; CDC42L2; WAS; RAC1B; SNAI1; CTNNB1; PVRL3; CSNK2A2; PTBP3
    AhR pathway CYP1A2; NQO1; JUN; CDKN1A; EGFR; CYP1A1; AIP; PTGES3; CDC37; CYP1B1
    Alpha6-Beta4 Integrin Signaling Pathway EGFR; EIF4EB; CDKN1A; PLEC; CD151; EIF4E; MST1R; COL17A1; DSP; CD151L
    Androgen receptor signaling pathway JUN; PSMC3IP; CCDC102A; RAD9A; KDM1A; GNB2L1; PATZ1; EFCAB6; RNF14; STUB1
    Arf6 signaling events EPHA2; ADRB2; EGF; EFNA1; FBXO8; ARAP2; AGTR1; USP6; GULP1; ADAP1

    egfr has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by egfr itself. We selected most functions egfr had, and list some proteins which have the same functions with egfr. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PKLR; SMC3; ROCK2; ADCY9; PIK3C2B; PANK1B; ABCG2C; TTLL11; KIF13B; CSNK1E
    MAP kinase kinase kinase activity MAP3K1; BRAF; STK3; ZAK; MAP3K5; EGFR; MAP3K12; RAF1; KIAA1804; MAP3K2
    actin filament binding TLN2A; CTNNA3; TMOD1; ADSSL1; SMYHC2; MYO1A; LCP1; TAGLN3A; PLDN; MYO7A
    chromatin binding NKX6-1; RNF2; YAP1; PKN1; ASCL1; TOX; REST; PSIP1; GLI2; CBX7
    double-stranded DNA binding DDX11; XRCC5; NEIL3; USF1; MTERF3; KIN; SP8B; TDP1; CTNNB1; YBX1
    enzyme binding GSTM3; RCOR3; SCARB2; HLCS; PPARG; DYM; IQCB1; LGALS9; DIS3L; C2orf56
    epidermal growth factor-activated receptor activity EGFR; EFEMP1
    identical protein binding AMOTL2; PTS; TRIM39; SOD1; CEP170L; PRPS2; TP53; SH3GLB1; MIEF1; GRB2
    contributes_to nitric-oxide synthase regulator activity EGFR
    protein binding TRDN; FPR1; SNAP47; SERPINB9; GUCY2C; SPAG5; TSPAN6; C11orf57; CDKL3; FAM50B
    protein heterodimerization activity DMRT1; ARNT2; HSPD1; CEBPB; HIST3H2BB; CUL3; UGT1A6A; CASP8; HER5; TAF8
    protein phosphatase binding PIK3R1; RPA2; ITPR1; PPP1R3G; STAT6; GRB2; MVP; CDH2; CTNNB1; Itga10&Itgb1
    protein tyrosine kinase activity FGFR1; SHC1; WEE2; TNK2B; KDRL; INSRA; CLK2; PDGFRB; AXL; BLK
    receptor signaling protein tyrosine kinase activity EGFRA; TYRO3; ERBB2; KIT; KITB; LYN; EGFR; ERBB4A; INSR; ERBB3B
    transmembrane receptor protein tyrosine kinase activity ALK; ERBB4; ROS1; DDR2; INSRA; EPHB2B; NTRK3; EGFRA; RYK; ERBB2
    transmembrane signaling receptor activity FZD8A; Fzd4; GPR98; FZD8B; THBD; FCAMR; TRPV1; CD5; SIGLEC8; CD4
    ubiquitin protein ligase binding PRDX6; SQSTM1; TXNIP; ZFP746; JAK1; TOLLIP; MC4R; UBE2G1A; TRIB3; SMAD5

    egfr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with egfr here. Most of them are supplied by our site. Hope this information will be useful for your research of egfr.

    N/A

    Fernandez-Ulibarri, I; Hammer, K; et al. Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity. INTERNATIONAL JOURNAL OF CANCER 136:2228-2240(2015).
    Wang, YJ; Zhang, CL; et al. Investigation of phase SPR biosensor for efficient targeted drug screening with high sensitivity and stability. SENSORS AND ACTUATORS B-CHEMICAL 209:313-322(2015).

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