Recombinant Human EPHA2

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Recombinant Human EPHA2

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Cat.No. : EPHA2-26740TH
Product Overview : Recombinant full length Human Eph receptor A2 with N terminal proprietary tag; Predicted MWt 135.30 kDa inclusive of tag.
Description : This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
Protein length : 976 amino acids
Molecular Weight : 135.300kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g., skin, intestine, lung, and ovary.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.Contains 2 fibronectin type-III domains.Contains 1 protein kinase domain.Contains 1 SAM (sterile alpha motif) domain.
Gene Name : EPHA2 EPH receptor A2 [ Homo sapiens ]
Official Symbol : EPHA2
Synonyms : EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2;
Gene ID : 1969
mRNA Refseq : NM_004431
Protein Refseq : NP_004422
MIM : 176946
Uniprot ID : P29317
Chromosome Location : 1p36
Pathway : Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Direct p53 effectors, organism-specific biosystem; EPHA forward signaling, organism-specific biosystem;
Function : ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity;

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