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Native Human FGF1

Cat.No. : FGF1-26203TH
Product Overview : Human FGF1.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.
Source : E. coli
Form : Lyophilised
Storage buffer : Preservative: NoneConstituents: 5mM Sodium phosphate, 100mM Sodium chloride, pH 8.0
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : Recombinant Human FGF1 is a 15.8 kDa protein containing 140 amino acid residues:MFNLPPGNYKKPKLLYCSNGGHFLR ILPDGTVDGTRDRSDQHIQLQLSAE SVGEVYIKSTETGQYLA MDT DGLLYGSQTPNEECLFLERLEENHY NTYISKKHAEK NWFVGLKKNGSCKRGPRTHYGQKAI LFLPLPVSSD
Sequence Similarities : Belongs to the heparin-binding growth factors family.
Gene Name : FGF1 fibroblast growth factor 1 (acidic) [ Homo sapiens ]
Official Symbol : FGF1
Synonyms : FGF1; fibroblast growth factor 1 (acidic); FGFA; heparin-binding growth factor 1; AFGF; ECGF; ECGF beta; ECGFA; ECGFB; endothelial cell growth factor; alpha; beta; FGF alpha; GLIO703; HBGF1; heparin binding growth factor 1;
Gene ID : 2246
mRNA Refseq : NM_000800
Protein Refseq : NP_000791
MIM : 131220
Uniprot ID : P05230
Chromosome Location : 5q31.3-q33.2
Pathway : Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1b ligand binding and activation, organism-specific biosystem;
Function : S100 alpha binding; fibroblast growth factor receptor binding; growth factor activity; heparin binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any clinical trials using FGF1 for heart disease? 06/28/2020

Yes, there have been clinical trials exploring the use of FGF1 in treating heart disease, specifically in promoting cardiac angiogenesis.

Can FGF1 be used in regenerative medicine? 09/15/2018

Yes, FGF1 is being investigated for its potential in regenerative medicine to repair damaged tissues and organs.

Can FGF1 be used in the treatment of diabetes? 03/29/2018

FGF1 has shown potential in improving insulin sensitivity and glucose regulation in preclinical studies, but further research is needed for clinical applications.

What safety concerns are associated with FGF1 use? 01/15/2017

Safety concerns include the risk of uncontrolled cell growth, which could lead to cancer, and the need for precise dosing and administration.

Are there any side effects associated with FGF1 therapy? 12/10/2016

Potential side effects may include inflammation at the application site, allergic reactions, and adverse effects related to uncontrolled cell growth.

Customer Reviews (3)

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Reviews
08/06/2021

    By using FGF1 protein, I can explore the mechanisms underlying cell division, cell cycle control, and the molecular pathways associated with these processes.

    06/03/2021

      The protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.

      11/25/2018

        As a researcher utilizing FGF1 protein in my trials, I can highlight its advantages and the valuable support provided by the manufacturer in facilitating my research.

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