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| Cat.No.: | FOLH1-31003TH |
| Product Overview: | Recombinant fragment of Human PSMA (amino acids 1-150) with proprietary tag, 43kDa. |
| Description: | This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. |
| Protein length: | 150 amino acids |
| Molecular Weight: | 43.000kDa inclusive of tags |
| Source: | E. coli |
| Tissue specificity: | Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kid |
| Form: | Liquid |
| Purity: | >90% by SDS-PAGE |
| Storage buffer: | pH: 7.50Constituents:0.79% Tris HCl, 0.31% Glutathione |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Sequences of amino acids: | MWNLLHETDS AVATARRPRW LCAGALVLAG GFFLLGFLFG WFIKSSNEAT NITPKHNMKAFLDELKAENI KKFLYNFTQI PHLAGTEQNF QLAKQIQSQW KEFGLDSVEL AHYDVLLSYPNKTHPNYISI INEDGNEIFN TSLFEPPPPG |
| Sequence Similarities: | Belongs to the peptidase M28 family. M28B subfamily. |
| Gene Name: | FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 [ Homo sapiens ] |
| Official Symbol: | FOLH1 |
| Synonyms: | FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; FOLH; glutamate carboxypeptidase 2; GCP2; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; NAALAD1; NAALAdase; PSM; PSMA; |
| Gene ID: | 2346 |
| mRNA Refseq: | NM_001014986 |
| Protein Refseq: | NP_001014986 |
| MIM: | 600934 |
| Uniprot ID: | Q04609 |
| Chromosome Location: | 11p11.2 |
| Pathway: | One Carbon Metabolism, organism-specific biosystem; Vitamin digestion and absorption, organism-specific biosystem; Vitamin digestion and absorption, conserved biosystem; |
| Function: | carboxypeptidase activity; dipeptidase activity; metal ion binding; metallopeptidase activity; peptidase activity; |
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